Results 121 to 130 of about 77,484 (271)

A 15-year-old Girl with a Lateral Neck Mass Turning Out to Be Papillary Thyroid Carcinoma - Lateral Ectopic Papillary Thyroid Carcinoma or Lymph Node Metastasis? [PDF]

Lateral neck lesions in children are common and involve various infectious or inflammatory etiologies, as well as embryological remnants such as branchial cleft cysts. Although unusual, ectopic thyroid tissue may also present as a lateral neck mass. Here,
Joep P.M Derikx, José C.C. Koppes, Esther Edelenbos, Christiaan F. Mooij, Joost van Schuppen, A.S. Paul van Trotsenburg, Marijke E.B. Kremer, Anton F. Engelsman, Arantza Farina-Sarasqueta   +8 more
core   +1 more source

Peri‐oesophageal metastases of pulmonary adenocarcinoma presenting as dysphagia in a dog

Australian Veterinary Journal, EarlyView.
Primary pulmonary neoplasia represents approximately one percent of canine cancers. Although it is recognised that many of these cases may not display classic respiratory signs, dysphagia is not an expected presentation. This report describes a twelve‐year‐old Border Collie that presented with a history of progressive dysphagia and weight loss over ...
JM Beattie, A Teh
wiley   +1 more source

Combining Transfer of TTF-1 and Pax-8 Gene: a Potential Strategy to Promote Radioiodine Therapy of Thyroid Carcinoma [PDF]

, 2011
Cotransfer of TTF-1 and Pax-8 gene to tumor cells, resulting in the reexpression of iodide metabolism-associated proteins, such as sodium iodide symporter (NIS), thyroglobulin (Tg), thyroperoxidase (TPO), offers the possibility of radioiodine therapy to ...
Da Mu, Suping Li, Rui Huang, Anren Kuang, Xiaojuan Ma   +4 more
core   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

CD93—An emerging vascular target in cancer therapy

British Journal of Pharmacology, EarlyView.
Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira, Stefano Barbera, Roberta Lugano, Anna Dimberg   +3 more
wiley   +1 more source

Skull base metastasis from papillary thyroid carcinoma: a report of three cases [PDF]

, 2015
Mutahir A Tunio,1 Mushabbab Al Asiri,2 Khalid Hussain Al-Qahtani,3 Sadiq Aldandan,4 Khalid Riaz,5 Yasser Bayoumi,6 1Radiation Oncology, King Fahad Medical City, Riyadh, Saudi Arabia; 2Radiation Oncology, Comprehensive Cancer Center, King Fahad Medical ...
Bayoumi Y, Aldandan S, Al-Qahtani KH, Riaz K, Tunio MA, Al Asiri M   +5 more
core  

RASD2 Drives Renal Clear Cell Carcinoma Progression via RAF1 (Ser338) Phosphorylation

Cancer Science, EarlyView.
RASD2 drives clear cell renal cell carcinoma (ccRCC) progression by physically interacting with RAF1 to induce its Ser338 phosphorylation, which subsequently activates the P38/ERK–MAPK signaling pathway to promote malignant tumor phenotypes and poor prognosis.
Jingxuan Yu, Gang Yu, Yuan Liu, Yu Zhou, Wei Liu, Lin Wang, Lide Liu, Yan Liu, Tiejun Pan, Zhenyu Liu, Lei Gao   +10 more
wiley   +1 more source

Morphological and immunohistochemical analysis in encapsulated follicular variant papillary thyroid carcinoma, invasive follicular variant papillary thyroid carcinoma and a new entity: non-invasive follicular thyroid neoplasm with papillary nuclear feature [PDF]

Thyroid cancers are the most common endocrine organ cancers. Encapsulated follicular variant papillary thyroid carcinomas (EFVPTC) are quite slow (indolent).
Zeliha Çelik, Naile Kökbudak, Pembe Oltulu, Fahriye Kilinç   +3 more
core   +1 more source

Evolving Pathology of Anaplastic Thyroid Carcinoma: Integrating Morphology, Immunohistochemistry, and Molecular Insights

Cancer Science, EarlyView.
Schematic overview of progression from differentiated thyroid carcinoma (DTC) to anaplastic thyroid carcinoma (ATC). ATC primarily develops via two pathways: the BRAF p.V600E‐mutated papillary thyroid carcinoma (PTC) pathway and the RAS‐mutated pathway. The origin and progression of BRAF/RAS‐wildtype ATC remain unclear.
Toru Odate, Tetsuo Kondo
wiley   +1 more source

circMAN1A2 as an Isoform‐Resolved Circular RNA Hub in Cancer

Cancer Science, EarlyView.
circMAN1A2 as an isoform‐resolved circular RNA hub in cancer. circMAN1A2 is generated by back‐splicing of MAN1A2 pre‐mRNA, with alternative circularization producing multiple isoforms, including the predominant circMAN1A2(2–5). Its mechanistic interfaces include miRNA‐associated regulation, RBP binding/proteostasis control, BSJ‐mediated RNA–RNA pairing,
Hanyu Shang, Hui Wang, Yonghang Xu, Lingyun Geng, Yanqing Wang   +4 more
wiley   +1 more source