Results 131 to 140 of about 186,793 (334)

DysRegNet: Patient‐specific and confounder‐aware dysregulated network inference towards precision therapeutics

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Gene regulation is frequently altered in diseases in unique and patient‐specific ways. Hence, personalised strategies have been proposed to infer patient‐specific gene‐regulatory networks. However, existing methods do not scale well because they often require recomputing the entire network per sample.
Johannes Kersting, Olga Lazareva, Zakaria Louadi, Jan Baumbach, David B. Blumenthal, Markus List   +5 more
wiley   +1 more source

Papillary Thyroid Carcinoma: Ectopic Malignancy versus Metastatic Disease

Case Reports in Endocrinology, 2017
Papillary thyroid carcinoma frequently metastasizes to regional lymph nodes. However, cervical lymph node metastasis as a sole manifestation of occult papillary thyroid carcinoma is rarely observed. Ectopic thyroid is an uncommon condition defined as the
Yanery's Agosto-Vargas, Madeleine Gutiérrez, J. H. Martínez, Michelle Mangual-García, Coromoto Palermo, Sharon Vélez-Maymi, L. Hernández-Vázquez, S. Miranda-Rodríguez, Alex González-Bóssolo, Ernesto Solá-Sánchez, Marianne Hernández-Negrón   +10 more
semanticscholar   +1 more source

Tyrosine kinase inhibitors for the therapy of anaplastic thyroid cancer [PDF]

, 2015
Anaplastic thyroid cancer (ATC) is often incurable so new therapeutic approaches are needed. Tyrosine kinases inhibitors (such as imanitib, sunitinib or sorafenib) are under evaluation for the treatment of ATC.
Bond JA, Cohen EE, Dowlati A, Goulart B, Grande E, Hayashi N, Ibrahim N, Klopper JP, Mahlknecht U, Ohta K, Ruggeri RM, Sherman SI   +11 more
core   +1 more source

Hypoxia Inhibitor Improves Iodine Uptake Disorder in Thyroid Cancer Through the hsa_circ_0023990/miR‐448/DNMT1/NIS Axis

Cancer Science, EarlyView.
Our study reveals that hypoxia inhibitors ameliorate iodine uptake dysfunction in thyroid cancer by acting on the hsa_circ_0023990/miR‐448/DNMT1/NIS signaling pathway. ABSTRACT This research seeks to investigate how hypoxia inhibitors enhance iodine uptake in thyroid cancer cells. Clinical samples were gathered and assessed for hsa_circ_0023990, DNMT1,
Ruiqin Gou, Shiqi Chen, Yangyang Lei, Pengqing Wu, Xuezhong Chen, Qing Zhang   +5 more
wiley   +1 more source

Roles of microRNA let-7b in papillary thyroid carcinoma by regulating HMGA2

Tumor Biology, 2017
The incidence of thyroid cancer has increased significantly in the last decade, and the most frequent type of this cancer is papillary thyroid carcinoma.
Hongguang Li, Lihong Zhao, Zhenhua Zhang, Heng Zhang, Chao Ding, Zijie Su   +5 more
doaj   +1 more source

Diagnosis of invasive encapsulated follicular variant papillary thyroid carcinoma by protein-based machine learning [PDF]

Journal of Pathology and Translational Medicine
Background Although the criteria for follicular-pattern thyroid tumors are well-established, diagnosing these lesions remains challenging in some cases.
Truong Phan-Xuan Nguyen, Minh-Khang Le, Sittiruk Roytrakul, Shanop Shuangshoti, Nakarin Kitkumthorn, Somboon Keelawat   +5 more
doaj   +1 more source

ACSM5 Regulates Ferroptosis in Hepatocellular Carcinoma by Up‐Regulating POR and Modulating Lipid Metabolism

Cancer Science, EarlyView.
ACSM5 induced ferroptosis in HCC by up‐regulating cytochrome P450 oxidoreductase (POR). The metabolic transformation of linoleic acid to arachidonic acid was also promoted by ACSM5; thereby, the sensitivity to ferroptosis was elevated. ABSTRACT The medium‐chain fatty acyl‐CoA synthetase‐5 (ACSM5) plays a crucial role in the development of some cancers.
Zhengqiang Wu, Xiaofeng Xiong, Mingyi Dong, Linfei Luo, Zixiang Huang, Kedong Xu, Lianwu Zhao, Fenfen Wang, Zhili Wen   +8 more
wiley   +1 more source

Malar Bone Metastasis Revealing a Papillary Thyroid Carcinoma

Case Reports in Otolaryngology, 2012
Papillary thyroid carcinoma is the most common form of differentiated thyroid carcinoma. It is generally confined to the neck with or without spread to regional lymph nodes.
Ihsen Slim, Aida Mhiri, Imène Meddeb, Aida Goucha, Saïd Gritli, Mohamed Faouzi Ben Slimene   +5 more
doaj   +1 more source

Occult metastasis from occult papillary carcinoma of the thyroid [PDF]

, 1967
Paul W. Gikas, Stanley S. Labow, Walter DiGiulio, John E. Finger   +3 more
openalex   +1 more source

Fine-needle aspiration diagnoses of noninvasive follicular variant of papillary thyroid carcinoma.

American Journal of Clinical Pathology, 2015
OBJECTIVES Endocrine pathologists are reconsidering whether tumors characterized as noninvasive follicular variant of papillary thyroid carcinoma (NFVPTC) warrant a diagnosis of carcinoma.
B. Howitt, Sue Chang, M. Eszlinger, R. Paschke, Michael G. Drage, J. Krane, J. Barletta   +6 more
semanticscholar   +1 more source