Results 51 to 60 of about 114,887 (311)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Knowledge among college students and employees of local health units about human papillomavirus and cervical cancer and its implications for public health strategies and vaccination

DST, 2022
Introduction: Human papillomavirus (HPV) is the most commonly diagnosed sexually transmitted infection worldwide. It is estimated that 70% of cervical cancer cases are related to high-risk HPV 16 and 18 types; and 90% of genital warts to HPV 6 and 11 ...
Edison Natal Fedrizzi, Walkíria Rodrigues de Freitas, Fabiana Gonçalves de Aguiar   +2 more
doaj  

Using focus groups to plan culturally acceptable primary cervical cancer screening in Grenada, West Indies

Revista Panamericana de Salud Pública, 2023
Objective. To document Grenadian women’s knowledge about cervical cancer and human papillomavirus (HPV) infection, as well as their attitudes towards primary cervical cancer screening methods. Methods.
Calisha Hyacinth-Purcell, Jeannine Sylvester-Gill, Edwin Sperr, Jane McPherson, Amy Baldwin   +4 more
doaj   +1 more source

Evaluation of TypeSeq, a Novel High-Throughput, Low-Cost, Next-Generation Sequencing-Based Assay for Detection of 51 Human Papillomavirus Genotypes. [PDF]

, 2019
BackgroundHuman papillomaviruses (HPV) cause over 500 000 cervical cancers each year, most of which occur in low-resource settings. Human papillomavirus genotyping is important to study natural history and vaccine efficacy. We evaluated TypeSeq, a novel,
Boland, Joseph, Cortes, Bernal, Cullen, Michael, CVT Group, Dunn, S Terence, Herrero, Rolando, Hildesheim, Allan, Kreimer, Aimée R, Mirabello, Lisa, Porras, Carolina, Quint, Wim, Roberson, David, Rodriguez, Ana Cecilia, Sampson, Joshua, Schiffman, Mark, Van Doorn, Leen-Jan, Wagner, Sarah, Walker, Joan, Wentzensen, Nicolas, Yeager, Meredith, Zuna, Rosemary   +20 more
core   +1 more source

Going beyond the individual: How state-level characteristics relate to HPV vaccine rates in the United States [PDF]

, 2019
Background The human papillomavirus (HPV) vaccine is an underutilized cancer control practice in the United States. Although individual contextual factors are known to impact HPV vaccine coverage rates, the impact of macro-level elements are still ...
Brownson, Ross C, Franco, Melissa, Mazzucca, Stephanie, Padek, Margaret   +3 more
core   +2 more sources

Diversity Patterns of Domestic Herbivore Viruses in China Reveal Transmission Dynamics with Disease Management Implications

Advanced Science, EarlyView.
This study performs pan‐viromic profiling of 14,529 samples from 5,710 domestic herbivores across five Chinese provinces, establishing the DhCN‐Virome (1,085,360 viral metagenomes). It reveals species/sample‐specific viromic signatures and cross‐species transmission dynamics, aiding unified disease control.
Yue Sun, Yong Li, Bagen Temur, Yuanqing Lin, Yuhang Liu, Le Yi, Zheng Sun, Gang Zhang, Jun Li, Yu Guo, Linchuan Li, Jinshan Cai, Wenliang Tian, Gen Meng, Lingling Jiang, Min Fang, Fuying Ding, Xuezhang Zhou, Changchun Tu, Biao He   +19 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Advancing prevention of sexually transmitted infections through point-of-care testing : target product profiles and landscape analysis [PDF]

, 2017
Objectives: Advancing the field of point-of-care testing (POCT) for STIs can rapidly and substantially improve STI control and prevention by providing targeted, essential STI services (case detection and screening).
Blondeel, Karel, Cordero, Joanna, Kiarie, James, Murtagh, Maurine, Peeling, Rosanna W, Toskin, Igor   +5 more
core   +1 more source

Evaluation of the burden of HPV-related hospitalizations as a useful tool to increase awareness: 2007–2017 data from the sicilian hospital discharge records [PDF]

, 2020
In light of the implementation of human papillomavirus (HPV) prevention strategies, epidemiological studies in different geographical areas are required in order to assess the impact of HPV-related diseases.
Amato L., Amodio E., Candiloro S., Casuccio A., Costantino C., Maranto M., Marrella A., Palmeri S., Pizzo S., Restivo V., Vitale F.   +10 more
core   +1 more source

SpatialESD: Spatial Ensemble Domain Detection in Spatial Transcriptomics

Advanced Science, EarlyView.
ABSTRACT Spatial transcriptomics (ST) measures gene expression while preserving spatial context within tissues. One of the key tasks in ST analysis is spatial domain detection, which remains challenging due to the complex structure of ST data and the varying performance of individual clustering methods. To address this, we propose SpatialESD, a Spatial
Hongyan Cao, Gaiqin Liu, Jingyi Xia, Runle Chen, Tong Wang, Xiaoling Yang, Ruiling Fang, Yanhong Luo, Ping Zeng, Hongmei Yu, Yanbo Zhang, Yuehua Cui   +11 more
wiley   +1 more source