Results 81 to 90 of about 1,357,951 (245)

PRC2.1 Coordinates Peri‐Nucleolar H3K27me3‐Enriched Heterochromatin Organization and NPM1 Pentamerization to Maintain Nucleolar Integrity

Advanced Science, EarlyView.
PRC2.1(PCL2)‐coordinated H3K27me3‐enriched PNH establishes a spatial scaffold crucial for nucleolar integrity. As a crucial coordinator, PCL2 links PRC2.1 to chromatin organization and NPM1 assembly. This network‐based model reveals how chromatin modifications and nucleolar components cooperatively maintain nucleolar architecture, revealing novel ...
Lina Zhu, Wenqin Wang, Shuyun Chen, Gangyi Zhu, Zhen Wu, Yue Gu, Jingwen Xiong, Xu Zhang, Heng Liu, Kyoichi Isono, Youming Zhang, Jingjing Cao, Xiangzhi Li   +12 more
wiley   +1 more source

Enhancing Maturation of Human Neuromuscular Organoids via Electrical Stimulation

Advanced Science, EarlyView.
A framework for on‐demand and non‐invasive exposure of human neuromuscular organoids (NMOs) to electrical stimuli is established to promote their maturation. The robustness and effectiveness of different stimulation regimes are evaluated via thorough characterization of organoid tissue structure and contraction capacity. Chronic electrical stimulation,
Chrysanthi‐Maria Moysidou, Inês Afonso Martins, Ismail Amr El‐Shimy, Iacopo Bicci, Donatella Cea, Christina Bukas, Isra Mekki, Mara‐Camelia Rusu, Aylin Nebol, Ines Lahmann, Marie Piraud, Enrico Klotzsch, Mina Gouti   +12 more
wiley   +1 more source

Coping with Contagious Diseases: A Global Perspective

Journal of Islamic International Medical College, 2022
Historically, when compared to other ailments, contagious infectious have been feared greater in contrast to other diseases. A contagious disease is an infectious condition that spreads easily (i.e., is communicated) when a pathogen is exposed through ...
Meh Para Siddique
doaj  

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

Sub‐Terahertz Memristor Switches Using MoS2 by Liquid–Liquid Interface Assembly

Advanced Science, EarlyView.
This work introduces application‐ready sub‐terahertz memristor switches fabricated from electrochemically exfoliated MoS2 nanosheets assembled at a liquid–liquid interface. The devices exhibit robust unipolar resistive switching, low insertion loss, and high isolation across 10–110 GHz.
Tomás Mingates, Mohamed E. Ghatas, Jonas Deuermeier, Adam G. Kelly, Joseph Neilson, Jonathan N. Coleman, Luís Mendes, João C. Vaz, Sérgio Matos, Luca Lucci, Antonio Clemente, Zdeněk Sofer, Luís M. Pessoa, Elvira Fortunato, Rodrigo Martins, Asal Kiazadeh   +15 more
wiley   +1 more source

Assistência e educação da infância pobre nas instituições educativas do Pará nos séculos XIX e XX

Revista Cocar, 2018
O objetivo deste trabalho foi identificar as principais instituições educativas destinadas à infância no estado do Pará, nos séculos XIX e XX, destacando aspectos da formação direcionada para as crianças nesses espaços. O estudo se constituiu em um levantamento de pesquisas sobre instituições paraenses concebidas para a infância pobre, no ...
Pinheiro, Welington da Costa, Alves, Laura Maria da Silva Araújo, da Costa, Luciana Dias   +2 more
openaire   +1 more source

O ENSINO DE FÍSICA NA ÁREA DE CIÊNCIAS NATURAIS NO ENSINO FUNDAMENTAL I E ENSINO FUNDAMENTAL II SEGUNDO OS PARÂMETROS CURRICULARES NACIONAIS

Revista do Professor de Física, 2017
O presente trabalho tem por objetivo verificar e relatar o que os Parâmetros Curriculares Nacionais (PCNs) sugerem a respeito de temas de Física nos Ensino Fundamental I e II na área de Ciências Naturais e comparar com o que os livros didáticos de Ciências analisados pelo Programa Nacional do Livro Didático (PNLD) 2016 e 2017 trazem a respeito.
Medeiros, Emerson Avelino, Loos, Marcio Rodrigo   +1 more
openaire   +3 more sources

Stem Cell Differentiation Disperses Transcriptional Clusters via a Conserved Surface‐Condensate Trajectory

Advanced Science, EarlyView.
Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg, Irina Wachter, Agnieszka Pancholi, Matthias Akyel, Yomna Gohar, Priya Kumar, Ana Miguel Fernandes, Yuzhi Bao, Alica Schmidt‐Heydt, Marcel Piepers, Alicia Günthel, Marcel Sobucki, Elisa Kämmer, Süheyla Eroğlu‐Kayıkçı, Stephan Allgeier, Sylvia Erhardt, Vasily Zaburdaev, Carmelo Ferrai, Lennart Hilbert   +18 more
wiley   +1 more source

Carcinoma neuroendocrino indiferenciado de parótida en hombre de 40 años de edad. Reporte de caso

Gaceta Mexicana de Oncolog�a
El carcinoma neuroendocrino de células pequeñas de las glándulas salivales representa aproximadamente el 2% de todas las neoplasias malignas de las glándulas salivales. Este tipo de tumores son extremadamente raros, solo se han descrito siete casos. Se presenta el caso de un paciente de sexo masculino de 40 años con una tumoración en mejilla izquierda,
Frida Y. Mendoza-Liera, Diego F. Almeida-Rodríguez, Sergio S. Romero-Mares   +2 more
openaire   +2 more sources

Concentration‐Driven Li+ Solvation Engineering with TDMAP‐Based Porphyrin Additives for Dendrite‐Free Li Metal Batteries

Advanced Science, EarlyView.
The electrolyte engineering of introducing tetrakis(4‐N, N‐dimethylaminophenyl)porphyrin (TDMAP) is designed to modulate Li+ solvation structure and solid electrolyte interphase, where the interaction with PF₆− anions is altered (Li+–NMe2–PF₆−). Consequently, the cells with optimal additive concentration achieve high Coulombic efficiency (∼99%), and ...
Pooria Afzali, Jian Wang, Sergio Rodriguez, Jin‐Hyun Chang, Luca Magagnin, Maximilian Fichtner   +5 more
wiley   +1 more source