Results 91 to 100 of about 6,451 (213)

Exome Sequencing of a Blastomycosis Case–Control Cohort From Manitoba and Northwestern Ontario, Canada

Mycoses, Volume 67, Issue 9, September 2024.
ABSTRACT Background Blastomycosis is a pulmonary disease caused by Blastomyces spp., a group of pathogenic dimorphic fungi endemic to a number of geographic regions, specifically Manitoba and northwestern Ontario, Canada. Immunosuppression is a major risk factor affecting disease susceptibility, yet host immunity is not well understood.
Paul Jankowski, Emma R. Lee, John Embil, Yoav Keynan, Paul J. McLaren   +4 more
wiley   +1 more source

From Mendel to mycoses: Immuno‐genomic warfare at the human–fungus interface

Immunological Reviews, Volume 322, Issue 1, Page 28-52, March 2024.
Summary Fungi are opportunists: They particularly require a defect of immunity to cause severe or disseminated disease. While often secondary to an apparent iatrogenic cause, fungal diseases do occur in the absence of one, albeit infrequently. These rare cases may be due to an underlying genetic immunodeficiency that can present variably in age of ...
Donald C. Vinh
wiley   +1 more source

NOD-Like Receptor P3 Inflammasome Controls Protective Th1/Th17 Immunity against Pulmonary Paracoccidioidomycosis

Frontiers in Immunology, 2017
The NOD-like receptor P3 (NLRP3) inflammasome is an intracellular multimeric complex that triggers the activation of inflammatory caspases and the maturation of IL-1β and IL-18, important cytokines for the innate immune response against pathogens.
C. Feriotti, E. F. de Araújo, F. V. Loures, T. A. da Costa, N. A. L. Galdino, D. Zamboni, V. Calich   +6 more
semanticscholar   +1 more source

Profile of total IgG, IgG1, IgG2, IgG3 and IgG4 levels in sera of patients with paracoccidioidomycosis: treatment follow-up using Mexo and rPb27 as antigens in an ELISA

Memorias do Instituto Oswaldo Cruz, 2012
The levels of total of IgG, IgG1, IgG2, IgG3 and IgG4 were evaluated in 54 patients with chronic paracoccidioidomycosis (PCM) before, during and after treatment using an enzyme-linked immunosorbent assay with Mexo and recombinant Pb27 (rPb27) as the ...
Lílian da Silva Santos, Viviane Cristina Fernandes, Samuel Gonçalves da Cruz, Weverton César Siqueira, Alfredo Miranda Goes, Ênio Roberto Pietra Pedroso   +5 more
doaj   +1 more source

Drug Repurposing for Paracoccidioidomycosis Through a Computational Chemogenomics Framework

Frontiers in Microbiology, 2019
Paracoccidioidomycosis (PCM) is the most prevalent endemic mycosis in Latin America. The disease is caused by fungi of the genus Paracoccidioides and mainly affects low-income rural workers after inhalation of fungal conidia suspended in the air.
A. A. de Oliveira, B. Neves, Lívia C Silva, C. M. Soares, C. Andrade, M. Pereira   +5 more
semanticscholar   +1 more source

Paracoccidioidomicocis: definición de las áreas endémicas de Colombia

Biomédica: revista del Instituto Nacional de Salud, 2000
Una enfermedad endémica es aquélla que se presenta constantemente en un área geográfica o en un grupo de población; la definición de endemia abarca, también, la prevalencia usual de una enfermedad en un área o grupo determinado.
Edilma Torrado, Elizabeth Castañeda, Fernando de la Hoz, Angela Restrepo   +3 more
doaj   +1 more source

Paracoccidioidomycosis after Highway Construction, Rio de Janeiro, Brazil

Emerging Infectious Diseases, 2017
Transmission of Paracoccidioides spp. fungi to humans is usually related to manipulation of soil. Rural workers are the most affected group. We report an outbreak of paracoccidioidomycosis after deforestation and massive earth removal during construction
A. C. D. do Valle, P. Marques de Macedo, Rodrigo Almeida-Paes, A. R. Romão, M. Lazéra, Bodo Wanke   +5 more
semanticscholar   +1 more source

Experimental Therapy of Paracoccidioidomycosis Using P10-Primed Monocyte-Derived Dendritic Cells Isolated From Infected Mice

Frontiers in Microbiology, 2019
Paracoccidioidomycosis (PCM) is an endemic mycosis in Latin American caused by the thermodimorphic fungi of the genus Paracoccidioides spp. Notably, a Th1 immune response is required to control PCM.
Leandro B. R. Silva, Cleison L. Taira, Lucas S. Dias, Ana C. O. Souza, Joshua D. Nosanchuk, Luiz R. Travassos, Carlos P. Taborda, Carlos P. Taborda   +7 more
doaj   +1 more source

Depletion of regulatory T cells in ongoing paracoccidioidomycosis rescues protective Th1/Th17 immunity and prevents fatal disease outcome

Scientific Reports, 2018
In human paracoccidioidomycosis (PCM), a primary fungal infection typically diagnosed when the disease is already established, regulatory T cells (Treg) cells are associated with disease severity.
N. A. L. Galdino, F. V. Loures, E. F. de Araújo, T. A. da Costa, N. Preite, V. Calich   +5 more
semanticscholar   +1 more source

Regulatory T cells in paracoccidioidomycosis

Virulence, 2018
This review addresses the role of regulatory T cells (Tregs), which are essential for maintaining peripheral tolerance and controlling pathogen immunity, in the host response against Paracoccidioides brasiliensis, a primary fungal pathogen.
V. Calich, R. Mamoni, F. V. Loures
semanticscholar   +1 more source