Results 31 to 40 of about 1,147,116 (292)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

A Critical Review of Mobile Learning: Phoenix, Fossil, Zombie or …..?

open access: yesEducation Sciences, 2021
The established mobile learning paradigm is now two decades old; it grew out of the visions and resources of e-learning research communities in universities in the world’s more economically developed regions.
John Traxler
doaj   +1 more source

Extra care housing: a paradigm shift [PDF]

open access: yes, 2007
This paper sets out to investigate if and how a spatial typology for extra care housing (ECH) can be defined within the context of housing for older people in the UK.
Hanson, J., Wojgani, H.
core  

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

The need for a locally relevant paradigm shift in Medical Education

open access: yesSri Lanka Journal of Medicine, 2016
The advent of technology over the past few decades has made a tremendous impact on the management of illnesses with concepts such as personalized genomic medicine being introduced.
Veranja Liyanaparthirana
doaj   +1 more source

Paradigm Shift [PDF]

open access: yes, 2011
This paper analyses the consequences of young researchers' scientifc choice on the dynamics of sciences. We develop a simple two state mean field game model to analyze the competition between two paradigms based on Kuhn's theory of scientifc revolutions.
Besancenot, Damien, Dogguy, Habib
core   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Valuing ecosystem services: A new paradigm shift [PDF]

open access: yes, 2006
The ways in which economists value natural resources has been, and continues to be, a constantly evolving process. At first, only transactions that took place in the marketplace were considered.
Kaval, Pamela
core   +1 more source

Wikileaks: A paradigm shift? [PDF]

open access: yes, 2012
Este artículo realiza un análisis mediológico de Wikileaks a partir de algunos conceptos clásicos de la Comunicación: transparencia, visibilidad, secreto, rumor, sospecha, líder de opinión, público y privado, sobreinformación. Del mismo modo, se describe
Magallón Rosa, Raúl
core   +4 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

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