Results 51 to 60 of about 2,115,235 (258)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Quasicrystals – A Paradigm Shift in Crystallography?
CHIMIA, 2014 The discovery of quasicrystals had important consequences for our understanding of long-range order in thermodynamic equilibrium, the definition of the term 'crystal' as well as diffraction theory.
Walter Steurer
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
A Paradigm Shift From Tradition To Modernity In Nollywoodas Projection Of African Narratives [PDF]
, 2012 The Nollywood movie industry since its inception in the early nineties has progressively projected the African cultural heritage to other parts of the world This encompasses both good and bad aspects of the culture Today many Africans in Diaspora ...
Ezenandu, P. E., Dr. Chris C. Ojukwu
core
Idiopathic recurrent pericarditis — a paradigm shift?
Российский кардиологический журнал, 2019 Idiopathic recurrent pericarditis (IRP) is a relatively rare inflammatory disease of the pericardium, often requiring emergency medical care, associated with a high percentage of temporary disability and significant economic costs.
V. Yu. Myachikova +3 more
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Contro l’attendismo bibliotecario: quadri di un’esposizione
AIB Studi, 2020 Il periodo dell’epidemia da Covid-19 ha fatto emergere in modo irrevocabile la necessità di un generale ripensamento dei comportamenti, dei valori prioritari, della socialità, della distribuzione delle risorse.
Luca Ferrieri
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Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Maxillary hollow-bulb obturator: A paradigm shift
The Journal of Indian Prosthodontic Society, 2019 Maxillary defects, whether congenital or acquired, make a patient encounter an array of physical and psychological difficulties, leading to an extremely poor quality of life.
Aanchal Rajesh Punjabi +3 more
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Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source