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A paradigm shift in international security as a consequence of the Russia-Ukraine war

This article presents the main features of the historical genesis of the international security paradigm shift from its institutionalisation to the present day.
Dmytro Dzvinchuk, Ołeksandr Radczenko
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Classifications of Sociological Paradigms

Encyclopedia
In this entry paper, we propose a brief analysis of the use of the notion of “paradigm” in sciences in general and in social sciences and sociology in particular.
Alexandru-Cosmin Apostol, Romeo Asiminei
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Marijuana Legalization and Decriminalization: A Paradigm Shift in Federal Policy

, 2014
Marijuana decriminalization and legalization have gone past being a trend and are settling in as federal policy, writes nonresident fellow Gary Hale, a 31-year veteran of the Drug Enforcement Administration. This policy brief includes recommendations for
Hale, Gary J.
core  

COVID-19: The Information Warfare Paradigm Shift

The Cyber Defense Review, 2020
Thomas Kuhn's The Structure of Scientific Revolutions highlights the critical term “paradigm shift,” which occurs when it suddenly becomes evident that earlier assumptions are no longer correct.
Jan Kallberg, Rosemary Burk, Bhavani Thuraisingham   +2 more
doaj   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Paradigm Shift in Spinal Surgery [PDF]

Neurospine, 2023
Hyeun-Sung Kim, Pang Hung Wu
doaj   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Paradigm shift

, 2020
A paradigm shift occurs when scientists stick to their model of reality (theory), while evidence begins to pile up that doesn 't fit in there. Often a group of relative outsiders is needed, for example a younger generation of scientists or scientists
Graaf, de, J.W. (Jan Willem)
core