Results 81 to 90 of about 1,182,762 (341)

Remission strategy in type 2 diabetes mellitus - a paradigm shift in the management of newly diagnosed patients

open access: yesSri Lanka Journal of Diabetes Endocrinology and Metabolism, 2019
No abstract ...
Prasad Katulanda   +2 more
doaj   +1 more source

Place-based policy and regional development in Europe [PDF]

open access: yes, 2010
The past two decades have seen a shift in the paradigm of regional policy in Europe. This article reviews the trends in regional policy design and delivery at national and European Union scales, and considers the degree to which the principles of place ...
Bachtler, John
core  

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento   +3 more
wiley   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin   +11 more
wiley   +1 more source

The Paradigm Shift [PDF]

open access: yesCanadian Association of Radiologists Journal, 2017
Peter L, Munk, Kieran J, Murphy
openaire   +2 more sources

Anti‐CD19 CAR T Cells in Autoimmune Encephalitis: Inflammation Controlled, Neurodegeneration Unchecked?

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Just recently, successful chimeric antigen receptor (CAR) T cell therapy was reported in the first patient with refractory, anti‐diacylglycerol lipase alpha (DAGLA) antibody‐mediated autoimmune encephalitis, achieving partial clinical remission.
Dimitrios Mougiakakos   +9 more
wiley   +1 more source

Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig   +9 more
wiley   +1 more source

Between continuity and paradigm shift: Pension reforms in Germany [PDF]

open access: yes
In general, the policy domain of old-age pensions is characterized by institutional continuity and only incremental reforms. Since the late 1980s, in Germany a series of public pension reforms, all initiated in view of imminent population aging, have ...
Hinrichs, Karl
core  

Use of a Molecular Signature Response Classifier to Inform Treatment Selection Improves Clinical Disease Activity Among Patients with Rheumatoid Arthritis Initiating a Biologic or Targeted Synthetic Disease‐Modifying Antirheumatic Drug

open access: yesArthritis Care &Research, EarlyView.
Objective We assessed the effectiveness of PrismRA to improve clinical outcomes among patients with rheumatoid arthritis (RA) initiating treatment with a biologic or targeted synthetic disease‐modifying antirheumatic drug (b/tsDMARD). Methods PrismRA incorporated 19 gene expression features and four clinical features to assess a patient's likelihood of
Fenglong Xie   +3 more
wiley   +1 more source

INCOME DISTRIBUTION POLICY IN THE NETHERLANDS: A PARADIGM SHIFT [PDF]

open access: yes
This paper investigates which different views have occurred on the main lines of the Dutch incomes policy. To this end the implications of the incomes policies pursued by different cabinets have been analyzed, mainly since 1973.
van der Hoek, M. Peter
core   +1 more source

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