Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Paradigm shift or shuffling the content? [PDF]
, 2021 Reflections on the 2018 Commission on RE Report with particular reference to the discussion of worldview that it ...
Cooling, T.
core
PARADIGM OF READING AND FUNCTIONAL LITERACY IN PRIMARY SCHOOL BY MEANS OF A FOREIGN LANGUAGE [PDF]
, 2021 The article considers the problem of literacy formation in primary school age. The categorical paradigm to understand "Reading literacy", "Functional literacy", "Reading competence" and "Reading activity" through the prism of domestic and European ...
Pyvovar, Y., Y. Pyvovar
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Editor’s Pick: Paradigm Shift in the Management of Gynaecological Cancers [PDF]
, 2015 In this review we highlight novel aspects of diagnostic imaging in gynaecological cancers, the paradigm shift in the surgical management of certain female pelvic cancers, as well as potential new molecular targeted therapies.
Philippe Van Trappen, Katelijn Sap
core
Parenting from the outside-in : reflections on parent training during a potential paradigm shift
, 2013 This article proposes that a paradigm shift that has implications for practitioners of parenting interventions is emerging. This shift represents a challenge to the dominant model of parent training.
Coyne, Joe
core +1 more source
The need for a locally relevant paradigm shift in Medical Education
Sri Lanka Journal of Medicine, 2016 The advent of technology over the past few decades has made a tremendous impact on the management of illnesses with concepts such as personalized genomic medicine being introduced.
Veranja Liyanaparthirana
doaj +1 more source
Phase transitions in paradigm shift models. [PDF]
PLoS ONE, 2013 Two general models for paradigm shifts, deterministic propagation model (DM) and stochastic propagation model (SM), are proposed to describe paradigm shifts and the adoption of new technological levels.
Huiseung Chae, Soon-Hyung Yook, Yup Kim
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source