Results 31 to 40 of about 1,182,762 (341)
A Paradigm Shift in Low Dose Radiation Biology [PDF]
, 2015 When ionizing radiation traverses biological material, some energy depositions occur and ionize directly deoxyribonucleic acid (DNA) molecules, the critical target. A classical paradigm in radiobiology is that the deposition of energy in the cell nucleus
Alatas, Z. (Z)
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FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Phase transitions in paradigm shift models. [PDF]
PLoS ONE, 2013 Two general models for paradigm shifts, deterministic propagation model (DM) and stochastic propagation model (SM), are proposed to describe paradigm shifts and the adoption of new technological levels.
Huiseung Chae, Soon-Hyung Yook, Yup Kim
doaj +1 more source
, 2011 This paper analyses the consequences of young researchers' scientifc choice on the dynamics of sciences. We develop a simple two state mean field game model to analyze the competition between two paradigms based on Kuhn's theory of scientifc revolutions.
Besancenot, Damien, Dogguy, Habib
core +2 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
The need for a locally relevant paradigm shift in Medical Education
Sri Lanka Journal of Medicine, 2016 The advent of technology over the past few decades has made a tremendous impact on the management of illnesses with concepts such as personalized genomic medicine being introduced.
Veranja Liyanaparthirana
doaj +1 more source
A Critical Review of Mobile Learning: Phoenix, Fossil, Zombie or …..?
Education Sciences, 2021 The established mobile learning paradigm is now two decades old; it grew out of the visions and resources of e-learning research communities in universities in the world’s more economically developed regions.
John Traxler
doaj +1 more source
Valuing ecosystem services: A new paradigm shift [PDF]
, 2006 The ways in which economists value natural resources has been, and continues to be, a constantly evolving process. At first, only transactions that took place in the marketplace were considered.
Kaval, Pamela
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source