Results 151 to 160 of about 254,286 (299)
Advanced Science, EarlyView.This study reveals that the Fgl2‐FcγRIIB signaling axis is a key mechanism by which MDSCs mediate tumor immune evasion. Tumor‐derived exosomes systemically activate MDSCs via this pathway, positioning this axis as a promising broad‐spectrum target for cancer immunotherapy.
Fenglin Lin +12 more
wiley +1 more source
Affectio Societatis, 2012 El presente trabajo de reflexión se propone indagar por la relación entre la matemática y el psicoanálisis y al mismo tiempo pensar sobre los fundamentos de la incomprensión que se plantea en el psicoanálisis, lo que nos llevará a otra relación, la de lo
José Fernando Sánchez
doaj
Haplotype‐Resolved 3D Genomic Landscapes and Their Impacts on Agronomic Traits in Grapevine
Advanced Science, EarlyView.This study presents a haplotype‐resolved 3D genomic landscape of grapevine, revealing that structural variations (SVs) are closely associated with phased topologically associating domain (TAD) boundary transitions. These rearrangements coordinate with allele‐specific DNA methylation (ASM) and allele‐biased gene expression (ASE) to shape key agronomic ...
Yanling Peng +18 more
wiley +1 more source
Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer
Advanced Science, EarlyView.Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen +13 more
wiley +1 more source
Bottom-up perspectives on hospital-wide patient flow - a multi-site qualitative study of solutions to organisational paradoxes. [PDF]
BMC Health Serv ResÅhlin P.
europepmc +1 more source
Inherently Disordered Auxetic Metamaterials
Advanced Science, EarlyView.Inherently disordered auxetic metamaterials based on random chiral Delaunay triangulations are designed and investigated using numerical simulations and experimental tests. These disordered frameworks exhibit orthotropic behavior and a large negative Poisson's ratio (ca.
Matteo Montanari +3 more
wiley +1 more source
Are “paradoxical emboli” really paradoxical? [PDF]
Clinical Cardiology, 2003 openaire +2 more sources
Corrigendum: Paradoxes weaken the International Association for the Study of Pain definition of pain. [PDF]
Korean J PainCohen ML, Weisman A, Quintner JL.
europepmc +1 more source
Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy
Advanced Science, EarlyView.Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu +4 more
wiley +1 more source