Results 191 to 200 of about 576,291 (256)

TRIM47 Regulates Energy Metabolism via Glycolytic Reprogramming to Drive Hepatocellular Carcinoma Progression and Represents an Efficient Therapeutic Target

Advanced Science, EarlyView.
This study identifies TRIM47 as a key driver of liver cancer progression by promoting glycolysis through ubiquitin‐mediated degradation of the gluconeogenic enzyme FBP1. TRIM47 enhances glucose uptake, lactate and ATP production, and tumor growth and metastasis.
Weijie Sun, Yihang Yuan, Qian Qiu, Kexuan Tan, Xutong Li, Haotian Li, Luyang Kang, Yuting Gu, Ziheng Zhang, Jiayu He, Jiali Li, Junjie Lin, Zihan Xie, Kexing Han, Jiabin Li, Yang Zhang, Ting Wu, Yufeng Gao   +17 more
wiley   +1 more source

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

Advanced Science, EarlyView.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, David Brenner, Francisco Pan‐Montojo, Eleonora Aronica, Markus Kipp, Vitaly Zimyanin, Jared Sterneckert, Torsten Grehl, Noah D. Seebacher, Tobias M. Böckers, Alberto Catanese, Brian J. Wainger, Patrick Oeckl, Min Ae Lee‐Kirsch, Andreas Hermann   +26 more
wiley   +1 more source

Diagnostic Value of Rapid On-Site Evaluation Combined With Prostate Biopsy in Prostate Cancer. [PDF]

Prostate
Ma H, Cao A, Hou H, Wu P, Wan B, Liu M.
europepmc   +1 more source

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

Turning Waste into Sensors: Sustainable Pesticide Detection Using Orange Peel-Derived Laser-Induced Graphene. [PDF]

ACS Omega
Santos FA, Correa DS.
europepmc   +1 more source

Assays of Angiogenic Potential Using Quail and Chicken Chorioallantoic Membrane (CAM). [PDF]

Curr Protoc
Fernandes LA, Magalhães GRI, Carreira ACO.   +2 more
europepmc   +1 more source

Applied Anatomical and Morphological Characterization of the Ocular Surface of the African Spiny Mice: Acomys cahirinus. [PDF]

Invest Ophthalmol Vis Sci
Guevara Montoya PA, Carrillo Y, Verma S, You H, Schill AW, Coates DR, Gesteira TF, Coulson-Thomas VJ.   +7 more
europepmc   +1 more source

Leakage-Proof and High-Conductivity Composite Phase Change Material Using Low-Melting-Point-Alloy-Encapsulated Copper Foam/Paraffin for Superior Thermal Homogeneity in Lithium-Ion Battery Modules. [PDF]

Materials (Basel)
He S, Zhao J, Ouyang D, Chen M.
europepmc   +1 more source

DNA extraction from long-term preserved formalin-fixed paraffin-embedded samples of thymic epithelial tumours - a performance comparison of three commercial kits. [PDF]

Contemp Oncol (Pozn)
Le DM, Nguyen TX, Dang TC, Tran ND, Nguyen NL, Dang TT, Nguyen TH, Nguyen HH, Nguyen DQ, Do TT.   +9 more
europepmc   +1 more source