Results 41 to 50 of about 592,831 (259)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Safety issues relating to paraffin usage in Eshane, Kwazulu-Natal

Journal of Energy in Southern Africa, 2017
This study describes results of a household survey conducted in Eshane in the rural Kwazulu-Natal Midlands in April 2002, including baseline sociodemographic, energy usage, paraffin-related injury and safety knowledge information.
R Matzopoulos, E Jordaan Jordaan, G Carolissen   +2 more
doaj   +1 more source

Research progress in carbon nanotube/paraffin phase change composites

Cailiao gongcheng, 2021
Paraffin phase change composite material (PPCCM) has attracted increasing attention and research from scholars at home and abroad because of its excellent latent heat value and high energy storage density.
DAI Yuan-zhe, TANG Bo, ZHANG Zhen-yu, REN Shou-long   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CFD analysis of paraffin-based hybrid (Co–Au) and trihybrid (Co–Au–ZrO2) nanofluid flow through a porous medium

Nanotechnology Reviews
Ternary hybrid nanofluids possess improved thermal characteristics, enhanced stability, better physical strength, and multi-functionality as compared to hybrid or usual nanofluids.
Yang Dezhi, Ahmad Sohail, Ali Kashif, Algarni Salem, Alqahtani Talal, Jamshed Wasim, Hussain Syed M., Irshad Kashif, Ahmad Hijaz   +8 more
doaj   +1 more source

Preparation and Properties of Paraffin/TiO₂/Active-carbon Composite Phase Change Materials

Cailiao gongcheng, 2016
A novel composite phase change materials (PCMs) of paraffin/TiO2/active-carbon was prepared by a microemulsion method, where paraffin acted as a PCM and titanium dioxide (TiO2) as matrix material, and a small amount of active carbon was added to improve ...
HAO Yong-gan, SHAO Xian-kun, TANG Hai-di, WANG Tao, LIU Jia-jia, LI Ben-xia   +5 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Development of Solar Accumulating Drying Equipment Based on the Theoretical Studies of Solar Energy Accumulation

Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2020
The process of heating a dewatered object in an infrared solar drying plant (with paraffin on the bottom) with solar energy storage is considered. To solve this problem, it is assumed that the heat capacity of paraffin exceeds the heat capacity of the ...
J. E. Safarov, Sh. A. Sultanova, G. T. Dadayev   +2 more
doaj   +1 more source