Results 191 to 200 of about 2,750 (239)

Parahydrogen‐Induced Polarization of a Labeled, Cancer‐Targeting DNA Aptamer

Angewandte Chemie - International Edition, 2023
Enhancing NMR signals of biomacromolecules by hyperpolarization offers exciting opportunities for diagnostic applications. However, their hyperpolarization via parahydrogen remains challenging as specific catalytic interactions are required, which are ...
Meike Emondts, Jürgen Klankermayer, Andreas Herrmann   +2 more
exaly   +2 more sources

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Parahydrogen-Polarized Fumarate for Preclinical in Vivo Metabolic Magnetic Resonance Imaging.

Journal of the American Chemical Society, 2023
We present a versatile method for the preparation of hyperpolarized [1-13C]fumarate as a contrast agent for preclinical in vivo MRI, using parahydrogen-induced polarization (PHIP).
Martin Gierse, Luca Nagel, Michael Keim, Sebastian Lucas, Tobias Speidel, Tobias Lobmeyer, G. Winter, Felix Josten, Senay Karaali, Maximilian Fellermann, Jochen Scheuer, Christoph Müller, Frits H. A. van Heijster, J. Skinner, J. Löffler, A. Parker, J. Handwerker, A. Marshall, Alon Salhov, Bilal El-Kassem, C. Vassiliou, J. Blanchard, R. Picazo-Frutos, James Eills, H. Barth, F. Jelezko, V. Rasche, F. Schilling, I. Schwartz, S. Knecht   +29 more
semanticscholar   +1 more source

Photo‐SABRE: Nuclear Spin Hyperpolarization of cis‐trans Photoswitchable Molecules by Parahydrogen

ChemPhotoChem, 2023
This work reports the enhancement of 23000 and 9200 times of the 15N nuclear spin polarization of cis and trans isomers of azobenzene, correspondingly, as compared to the thermal NMR signals at 9.4 T by exploiting Signal Amplification by Reversible ...
A. Kiryutin, Vitaly P. Kozinenko, A. Yurkovskaya   +2 more
semanticscholar   +1 more source

Unconventional Parahydrogen-Induced Hyperpolarization Effects in Chemistry and Catalysis: From Photoreactions to Enzymes [PDF]

ACS Catalysis
Nuclear spin hyperpolarization utilizing parahydrogen has the potential for broad applications in chemistry, catalysis, biochemistry, and medicine.
Andrey N Pravdivtsev, Ben J Tickner, Stefan Glöggler   +2 more
exaly   +2 more sources

Iron-Catalyzed Parahydrogen Induced Polarization

Journal of the American Chemical Society, 2023
Parahydrogen induced polarization (PHIP) can address the low sensitivity problem intrinsic to nuclear magnetic resonance spectroscopy. Using a catalyst capable of reacting with parahydrogen and substrate in either a hydrogenative or nonhydrogenative ...
Daniel C Najera, Alison R. Fout
semanticscholar   +1 more source

Parahydrogen hyperpolarized NMR detection of underivatized short oligopeptides.

In Analysis, 2023
Parahydrogen hyperpolarization has evolved into a versatile tool in NMR, allowing substantial sensitivity enhancements in analysis of biological samples.
Nele Reimets, Kerti Ausmees, S. Vija, A. Trummal, Merle Uudsemaa, I. Reile   +5 more
semanticscholar   +1 more source

Exceptionally Mild and High-Yielding Synthesis of Vinyl Esters of Alpha-Ketocarboxylic Acids, Including Vinyl Pyruvate, for Parahydrogen-Enhanced Metabolic Spectroscopy and Imaging.

Journal of Organic Chemistry, 2023
Metabolic changes often occur long before pathologies manifest and treatment becomes challenging. As key elements of energy metabolism, α-ketocarboxylic acids (α-KCA) are particularly interesting, e.g., as the upregulation of pyruvate to lactate ...
A. Brahms, Andrey N. Pravdivtsev, Lynn Thorns, F. Sönnichsen, Jan‐Bernd Hövener, R. Herges   +5 more
semanticscholar   +1 more source

Hyperpolarizing Water with Parahydrogen

ChemPhysChem, 2017
AbstractStudies of water‐based systems are of fundamental interest for nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) as water is the most abundant and important medium for global living. Hence, increasing the polarization of water and dissolved compounds is particularly attractive for biomedical applications such as ...
Sören Lehmkuhl, Meike Emondts, Lukas Schubert, Peter Spannring, Jürgen Klankermayer, Bernhard Blümich, P. Philipp M. Schleker   +6 more
openaire   +3 more sources

Parahydrogen-Induced Carbon-13 Radiofrequency Amplification by Stimulated Emission of Radiation

Angewandte Chemie, 2022
The feasibility of Carbon-13 Radiofrequency (RF) Amplification by Stimulated Emission of Radiation (C-13 RASER) is demonstrated on a bolus of liquid hyperpolarized ethyl [1-13C]acetate.
Christopher Nelson, A. Schmidt, Isaiah Adelabu, Shiraz Nantogma, V. Kiselev, Abubakar Abdurraheem, Henri de Maissin, Soeren Lehmkuhl, S. Appelt, T. Theis, E. Chekmenev   +10 more
semanticscholar   +1 more source

PIMC simulations of solid parahydrogen

Physical Review B, 1991
We have evaluated the kinetic energy of the center of mass of solid parahydrogen at T=18.9 K, and four different densities, by means of path-integral Monte Carlo computer simulation, using the pairwise additive Lennard-Jones potential. The results have been compared with the available experimental neutron data of Herwig et al. [Phys. Rev.
, Zoppi, , Neumann
openaire   +2 more sources