Results 1 to 10 of about 51,213 (265)
Parahydrogen‐Based Hyperpolarization for Biomedicine
Angewandte Chemie - International Edition, 2018 AbstractMagnetic resonance (MR) is one of the most versatile and useful physical effects used for human imaging, chemical analysis, and the elucidation of molecular structures. However, its full potential is rarely used, because only a small fraction of the nuclear spin ensemble is polarized, that is, aligned with the applied static magnetic field ...
Thomas Theis +2 more
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Parahydrogen‐Induced Hyperpolarization of Gases
Angewandte Chemie - International Edition, 2020 AbstractImaging of gases is a major challenge for any modality including MRI. NMR and MRI signals are directly proportional to the nuclear spin density and the degree of alignment of nuclear spins with applied static magnetic field, which is called nuclear spin polarization.
Thomas Theis +2 more
exaly +4 more sources
Microbiology Spectrum, 2023 Shigellosis caused by Shigella is one of the most important foodborne illnesses in global health, but little is known about the metabolic cross talk between this bacterial pathogen and its host cells during the different stages of the infection process ...
Ke-Chuan Wang +3 more
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Hyperpolarized 13C NMR for longitudinal in-cell metabolism using a mobile 3D cell culture system
Journal of Magnetic Resonance Open, 2023 Hyperpolarization with the dissolution dynamic nuclear polarization (dDNP) technique yields > 10,000-fold signal increases for NMR-active nuclei (e.g. 13C).
T.B.W. Mathiassen +7 more
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Hyperpolarized Carbon-13 MRI in Breast Cancer
Diagnostics, 2023 One of the hallmarks of cancer is metabolic reprogramming, including high levels of aerobic glycolysis (the Warburg effect). Pyruvate is a product of glucose metabolism, and 13C-MR imaging of the metabolism of hyperpolarized (HP) [1-13C]pyruvate (HP 13C ...
Ramona Woitek, Kevin M. Brindle
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Toxins, 2021 The voltage-gated sodium channel Nav1.8 is linked to neuropathic and inflammatory pain, highlighting the potential to serve as a drug target. However, the biophysical mechanisms that regulate Nav1.8 activation and inactivation gating are not completely ...
Tarek Mohamed Abd El-Aziz +11 more
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Electrical Pacing of Cardiac Tissue Including Potassium Inward Rectification. [PDF]
PLoS ONE, 2015 In this study cardiac tissue is stimulated electrically through a small unipolar electrode. Numerical simulations predict that around an electrode are adjacent regions of depolarization and hyperpolarization.
Suran Galappaththige, Bradley J Roth
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Non-Invasive Analysis of Human Liver Metabolism by Magnetic Resonance Spectroscopy
Metabolites, 2021 The liver is a key node of whole-body nutrient and fuel metabolism and is also the principal site for detoxification of xenobiotic compounds. As such, hepatic metabolite concentrations and/or turnover rates inform on the status of both hepatic and ...
John G. Jones
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Transportable hyperpolarized metabolites [PDF]
Nature Communications, 2017 Abstract Nuclear spin hyperpolarization of 13 C-labelled metabolites by dissolution dynamic nuclear polarization can enhance the NMR signals of metabolites by several orders of magnitude, which has enabled in vivo metabolic imaging by ...
Ji, Xiao +8 more
openaire +6 more sources
Metabolites, 2022 The liver plays an important role in whole-body glucose homeostasis by taking up glucose from and releasing glucose into the blood circulation. In the postprandial state, excess glucose in the blood circulation is stored in hepatocytes as glycogen.
Ayhan Gursan, Jeanine J. Prompers
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