Results 1 to 10 of about 87,929 (156)

Formate Metabolism in Shigella flexneri and Its Effect on HeLa Cells at Different Stages during the Infectious Process

Microbiology Spectrum, 2023
Shigellosis caused by Shigella is one of the most important foodborne illnesses in global health, but little is known about the metabolic cross talk between this bacterial pathogen and its host cells during the different stages of the infection process ...
Ke-Chuan Wang, Mathilde Hauge Lerche, Jan Henrik Ardenkjær-Larsen, Pernille Rose Jensen   +3 more
doaj   +1 more source

Hyperpolarized 13C NMR for longitudinal in-cell metabolism using a mobile 3D cell culture system

Journal of Magnetic Resonance Open, 2023
Hyperpolarization with the dissolution dynamic nuclear polarization (dDNP) technique yields > 10,000-fold signal increases for NMR-active nuclei (e.g. 13C).
T.B.W. Mathiassen, A.E. Høgh, M. Karlsson, S. Katsikis, K. Wang, M. Pennestri, J.H. Ardenkjær-Larsen, P.R. Jensen   +7 more
doaj   +1 more source

Hyperpolarized Carbon-13 MRI in Breast Cancer

Diagnostics, 2023
One of the hallmarks of cancer is metabolic reprogramming, including high levels of aerobic glycolysis (the Warburg effect). Pyruvate is a product of glucose metabolism, and 13C-MR imaging of the metabolism of hyperpolarized (HP) [1-13C]pyruvate (HP 13C ...
Ramona Woitek, Kevin M. Brindle
doaj   +1 more source

Identification and Characterization of Novel Proteins from Arizona Bark Scorpion Venom That Inhibit Nav1.8, a Voltage-Gated Sodium Channel Regulator of Pain Signaling

Toxins, 2021
The voltage-gated sodium channel Nav1.8 is linked to neuropathic and inflammatory pain, highlighting the potential to serve as a drug target. However, the biophysical mechanisms that regulate Nav1.8 activation and inactivation gating are not completely ...
Tarek Mohamed Abd El-Aziz, Yucheng Xiao, Jake Kline, Harold Gridley, Alyse Heaston, Klaus D. Linse, Micaiah J. Ward, Darin R. Rokyta, James D. Stockand, Theodore R. Cummins, Luca Fornelli, Ashlee H. Rowe   +11 more
doaj   +1 more source

Electrical Pacing of Cardiac Tissue Including Potassium Inward Rectification. [PDF]

PLoS ONE, 2015
In this study cardiac tissue is stimulated electrically through a small unipolar electrode. Numerical simulations predict that around an electrode are adjacent regions of depolarization and hyperpolarization.
Suran Galappaththige, Bradley J Roth
doaj   +1 more source

Non-Invasive Analysis of Human Liver Metabolism by Magnetic Resonance Spectroscopy

Metabolites, 2021
The liver is a key node of whole-body nutrient and fuel metabolism and is also the principal site for detoxification of xenobiotic compounds. As such, hepatic metabolite concentrations and/or turnover rates inform on the status of both hepatic and ...
John G. Jones
doaj   +1 more source

Magnetic Resonance Imaging and Spectroscopy Methods to Study Hepatic Glucose Metabolism and Their Applications in the Healthy and Diabetic Liver

Metabolites, 2022
The liver plays an important role in whole-body glucose homeostasis by taking up glucose from and releasing glucose into the blood circulation. In the postprandial state, excess glucose in the blood circulation is stored in hepatocytes as glycogen.
Ayhan Gursan, Jeanine J. Prompers
doaj   +1 more source

RNA interference reveals the escape response mechanism of Paramecium to mechanical stimulation

Biophysics and Physicobiology, 2023
In Paramecium, a mechanical stimulus applied to the posterior portion of the cell causes a transient increase in membrane permeability to potassium ions, transiently rendering the membrane in a hyperpolarized state.
Manabu Hori, Takashi Tominaga, Masaki Ishida, Mutsumi Kawano   +3 more
doaj   +1 more source

Optical Dynamic Nuclear Polarization of ¹³C Spins in Diamond at a Low Field with Multi-Tone Microwave Irradiation

Molecules, 2022
Majority of dynamic nuclear polarization (DNP) experiments have been requiring helium cryogenics and strong magnetic fields for a high degree of nuclear polarization. In this work, we instead demonstrate an optical hyperpolarization of naturally abundant
Vladimir V. Kavtanyuk, Hyun Joon Lee, Sangwon Oh, Keunhong Jeong, Jeong Hyun Shim   +4 more
doaj   +1 more source

Pilot Quality-Assurance Study of a Third-Generation Batch-Mode Clinical-Scale Automated Xenon-129 Hyperpolarizer

Molecules, 2022
We present a pilot quality assurance (QA) study of a clinical-scale, automated, third-generation (GEN-3) 129Xe hyperpolarizer employing batch-mode spin-exchange optical pumping (SEOP) with high-Xe densities (50% natural abundance Xe and 50% N2 in ~2.6 ...
Jonathan R. Birchall, Md Raduanul H. Chowdhury, Panayiotis Nikolaou, Yuri A. Chekmenev, Anton Shcherbakov, Michael J. Barlow, Boyd M. Goodson, Eduard Y. Chekmenev   +7 more
doaj   +1 more source