Results 1 to 10 of about 61,022 (308)

Hyperpolarization methods for MRS [PDF]

, 2015
© 2015 John Wiley & Sons, Ltd. This article covers the fundamental principles and practice of NMR hyperpolarization techniques, which are proving useful for in vivo magnetic resonance spectroscopy (MRS) studies of metabolism in animal models, and ...
Birchall, Jonathan R., Shchepin, Roman V., Skinner, Jason G., Boyd M. Goodson, Eduard Y. Chekmenev, Nicholas Whiting, Jonathan R. Birchall, Whiting, Nicholas, Chekmenev, Eduard Y., Max E. Gemeinhardt, Nikolaou, Panayiotis, Barlow, Michael J., Michael J. Barlow, Gust, Brogan M., Aaron M. Coffey, Brogan M. Gust, Shi, Fan, Roman V. Shchepin, Goodson, Boyd M., Gemeinhardt, Max E., Coffey, Aaron M., Jason G. Skinner, Panayiotis Nikolaou, Fan Shi   +23 more
core   +3 more sources

Hyperpolarization and the endothelium

Current Opinion in Physiology, 2023
The ability of vascular endothelial cells to generate and conduct membrane hyperpolarization is a critical integrative mechanism controlling local blood flow and systemic blood pressure.
Garland, Christopher, Kim A Dora, Dora, KA, Christopher J Garland   +3 more
core   +3 more sources

Optogenetic Hyperpolarization of Cardiomyocytes Terminates Ventricular Arrhythmia [PDF]

Frontiers in Physiology, 2019
Cardiac defibrillation to terminate lethal ventricular arrhythmia (VA) is currently performed by applying high energy electrical shocks. In cardiac tissue, electrical shocks induce simultaneously de- and hyperpolarized areas and only depolarized areas ...
Maximilian Funken, Maximilian Funken, Daniela Malan, Philipp Sasse, Tobias Bruegmann, Tobias Bruegmann, Tobias Bruegmann, Tobias Bruegmann   +7 more
doaj   +3 more sources

Bulk Hyperpolarization of Inorganic Materials

CHIMIA, 2021
Solid-state NMR spectroscopy is a well-established method to obtain atomic-level information about the structure of inorganic materials, but its use is often limited by low sensitivity.
Emsley, Lyndon, Björgvinsdóttir, Snædís   +1 more
core   +6 more sources

A Controlled System for Parahydrogen Hyperpolarization Experiments

Molecules
Parahydrogen-induced hyperpolarization (PHIP), introduced nearly four decades ago, provides an elegant solution to one of the fundamental limitations of nuclear magnetic resonance (NMR)—its notoriously low sensitivity.
Lorenzo Franco, Federico Floreani, Salvatore Mamone, Ahmed Mohammed Faramawy, Marco Ruzzi, Cristina Tubaro, Gabriele Stevanato   +6 more
doaj   +2 more sources

Formate Metabolism in Shigella flexneri and Its Effect on HeLa Cells at Different Stages during the Infectious Process

Microbiology Spectrum, 2023
Shigellosis caused by Shigella is one of the most important foodborne illnesses in global health, but little is known about the metabolic cross talk between this bacterial pathogen and its host cells during the different stages of the infection process ...
Ke-Chuan Wang, Mathilde Hauge Lerche, Jan Henrik Ardenkjær-Larsen, Pernille Rose Jensen   +3 more
doaj   +1 more source

Hyperpolarized 13C NMR for longitudinal in-cell metabolism using a mobile 3D cell culture system

Journal of Magnetic Resonance Open, 2023
Hyperpolarization with the dissolution dynamic nuclear polarization (dDNP) technique yields > 10,000-fold signal increases for NMR-active nuclei (e.g. 13C).
T.B.W. Mathiassen, A.E. Høgh, M. Karlsson, S. Katsikis, K. Wang, M. Pennestri, J.H. Ardenkjær-Larsen, P.R. Jensen   +7 more
doaj   +1 more source

Hyperpolarized Carbon-13 MRI in Breast Cancer

Diagnostics, 2023
One of the hallmarks of cancer is metabolic reprogramming, including high levels of aerobic glycolysis (the Warburg effect). Pyruvate is a product of glucose metabolism, and 13C-MR imaging of the metabolism of hyperpolarized (HP) [1-13C]pyruvate (HP 13C ...
Ramona Woitek, Kevin M. Brindle
doaj   +1 more source

Identification and Characterization of Novel Proteins from Arizona Bark Scorpion Venom That Inhibit Nav1.8, a Voltage-Gated Sodium Channel Regulator of Pain Signaling

Toxins, 2021
The voltage-gated sodium channel Nav1.8 is linked to neuropathic and inflammatory pain, highlighting the potential to serve as a drug target. However, the biophysical mechanisms that regulate Nav1.8 activation and inactivation gating are not completely ...
Tarek Mohamed Abd El-Aziz, Yucheng Xiao, Jake Kline, Harold Gridley, Alyse Heaston, Klaus D. Linse, Micaiah J. Ward, Darin R. Rokyta, James D. Stockand, Theodore R. Cummins, Luca Fornelli, Ashlee H. Rowe   +11 more
doaj   +1 more source

Transportable hyperpolarized metabolites [PDF]

Nature Communications, 2017
Abstract Nuclear spin hyperpolarization of 13 C-labelled metabolites by dissolution dynamic nuclear polarization can enhance the NMR signals of metabolites by several orders of magnitude, which has enabled in vivo metabolic imaging by ...
Ji, Xiao, Bornet, Aurélien, Vuichoud, Basile, Milani, Jonas, Gajan, David, Rossini, Aaron J., Emsley, Lyndon, Bodenhausen, Geoffrey, Jannin, Sami   +8 more
openaire   +6 more sources