Results 11 to 20 of about 88,078 (299)

Transportable hyperpolarized metabolites [PDF]

Nature Communications, 2017
Abstract Nuclear spin hyperpolarization of 13 C-labelled metabolites by dissolution dynamic nuclear polarization can enhance the NMR signals of metabolites by several orders of magnitude, which has enabled in vivo metabolic imaging by ...
Ji, Xiao, Bornet, Aurélien, Vuichoud, Basile, Milani, Jonas, Gajan, David, Rossini, Aaron J., Emsley, Lyndon, Bodenhausen, Geoffrey, Jannin, Sami   +8 more
openaire   +6 more sources

Signaling Roleplay between Ion Channels during Mammalian Sperm Capacitation

Biomedicines, 2023
In order to accomplish their primary goal, mammalian spermatozoa must undergo a series of physiological, biochemical, and functional changes crucial for the acquisition of fertilization ability.
Filip Benko, Dana Urminská, Michal Ďuračka, Eva Tvrdá   +3 more
doaj   +1 more source

Micro-Slab Coil Design for Hyperpolarized Metabolic Flux Analysis in Multiple Samples

Bioengineering, 2022
Abnormal metabolism is a hallmark of cancer cells. Accumulating evidence suggests that metabolic changes are likely to occur before other cellular responses in cancer cells upon drug treatment.
Geonhui Lee, Thomas Ruan, Claudia Wong, Kofi Deh, Alli Abolarin, Alexander Correa, Kayvan R. Keshari, Sangmoo Jeong   +7 more
doaj   +1 more source

Enhanced Optical 13C Hyperpolarization in Diamond Treated by High-Temperature Rapid Thermal Annealing [PDF]

, 2020
Methods of optical dynamic nuclear polarization open the door to the replenishable hyperpolarization of nuclear spins, boosting their nuclear magnetic resonance/imaging signatures by orders of magnitude.
Aguilar, A, Ajoy, A, Druga, E, Gierth, M, Krespach, V, Le, S, Lv, X, Meriles, CA, Nirodi, R, Nunn, N, Pines, A, Raghavan, P, Reimer, JA, Shames, AI, Shen, M, Shenderova, O, Torelli, M, Zaitsev, A, Zhao, R   +18 more
core   +1 more source

Hyperpolarized para-Ethanol [PDF]

The Journal of Physical Chemistry B, 2015
We show that an imbalance between the populations of singlet (S) and triplet (T) states in pairs of magnetically equivalent spins can be generated by dissolution dynamic nudear polarization: In partly deuterated ethanol ((CD3CH2OD)-C-13), this T/S imbalance can be transferred by cross-relaxation to observable, enhanced signals of protons and coupled C ...
Mammoli, Daniele, Vuichoud, Basile, Bornet, Aurélien, Milani, Jonas, Dumez, Jean-Nicolas, Jannin, Sami, Bodenhausen, Geoffrey   +6 more
openaire   +4 more sources

Hyperpolarized NMR metabolomics

Current Opinion in Chemical Biology, 2023
Hyperpolarized NMR is a promising approach to address the sensitivity limits of conventional NMR metabolomics approaches, which currently fails to detect minute metabolite concentrations in biological samples. This review describes how tremendous signal enhancement offered by dissolution-dynamic nuclear polarization and parahydrogen-based techniques ...
Ribay, Victor, Praud, Clément, Letertre, Marine P.M., Dumez, Jean-Nicolas, Giraudeau, Patrick   +4 more
openaire   +3 more sources

Hyperpolarized Views on the Roles of the Hyperpolarization-Activated Channels in Neuronal Excitability [PDF]

Epilepsy Currents, 2010
Upregulated H-Current in Hyperexcitable CA1 Dendrites after Febrile Seizures. Dyhrfjeld-Johnsen J, Morgan RJ, Csaba Foldy, Soltesz I., Front Cell Neurosci. 2008;2:2. doi:10.3389/neuro.03.002.2008. Somatic recordings from CA1 pyramidal cells indicated a persistent upregulation of the h-current ( Ih) after experimental febrile seizures.
Noam, Yoav, Baram, Tallie Z
openaire   +5 more sources

Hyperpolarized MR Imaging: Neurologic Applications of Hyperpolarized Metabolism [PDF]

American Journal of Neuroradiology, 2009
Hyperpolarization is the general term for a method of enhancing the spin-polarization difference of populations of nuclei in a magnetic field. No less than 5 distinct techniques (dynamic nuclear polarization [DNP]; parahydrogen-induced polarization-parahydrogen and synthesis allow dramatically enhanced nuclear alignment [PHIP-PASADENA]; xenon/helium ...
B D, Ross, P, Bhattacharya, S, Wagner, T, Tran, N, Sailasuta   +4 more
openaire   +2 more sources

A Minimal Model Shows that a Positive Feedback Loop Between sNHE and SLO3 can Control Mouse Sperm Capacitation

Frontiers in Cell and Developmental Biology, 2022
When mammalian spermatozoa are released in the female reproductive tract, they are incapable of fertilizing the oocyte. They need a prolonged exposure to the alkaline medium of the female genital tract before their flagellum gets hyperactivated and the ...
Bertrand de Prelle, Pascale Lybaert, David Gall   +2 more
doaj   +1 more source

Investigation of room temperature multispin-assisted bulk diamond 13C hyperpolarization at low magnetic fields [PDF]

, 2018
In this work we investigated the time behavior of the polarization of bulk 13C nuclei in diamond above the thermal equilibrium. This nonthermal nuclear hyperpolarization is achieved by cross relaxation between two nitrogen related paramagnetic defect ...
Abel, Bernd, Haase, Jürgen, Kohlrautz, Jonas, Meijer, Jan, Wunderlich, Ralf   +4 more
core   +2 more sources