Results 1 to 10 of about 2,821 (200)

Parahydrogen‐Induced Polarization of Amino Acids [PDF]

Angewandte Chemie - International Edition, 2021
Nuclear magnetic resonance (NMR) has become a universal method for biochemical and biomedical studies, including metabolomics, proteomics, and magnetic resonance imaging (MRI).
Jan-Bernd Hövener, Andrey Pravdivtsev, Simon Duckett   +2 more
exaly   +6 more sources

Parahydrogen‐Based Hyperpolarization for Biomedicine

Angewandte Chemie - International Edition, 2018
NMR is one of the most versatile and useful physical effects used for human imaging, chemical analysis and the elucidation of molecular structures. Yet, the full potential of NMR is hardly ever used, because only a small fraction of the nuclear spin ...
Thomas Theis, Jan-Bernd Hövener, Kirill Kovtunov   +2 more
exaly   +8 more sources

A Controlled System for Parahydrogen Hyperpolarization Experiments [PDF]

Molecules
Parahydrogen-induced hyperpolarization (PHIP), introduced nearly four decades ago, provides an elegant solution to one of the fundamental limitations of nuclear magnetic resonance (NMR)—its notoriously low sensitivity.
Lorenzo Franco, Federico Floreani, Salvatore Mamone, Ahmed Mohammed Faramawy, Marco Ruzzi, Cristina Tubaro, Gabriele Stevanato   +6 more
doaj   +5 more sources

Parahydrogen‐Polarized [1‐13C]Pyruvate for Reliable and Fast Preclinical Metabolic Magnetic Resonance Imaging

Advanced Science, 2023
Hyperpolarization techniques increase nuclear spin polarization by more than four orders of magnitude, enabling metabolic MRI. Even though hyperpolarization has shown clear value in clinical studies, the complexity, cost and slowness of current equipment
Luca Nagel, Martin Gierse, Wolfgang Gottwald, Zumrud Ahmadova, Martin Grashei, Pascal Wolff, Felix Josten, Senay Karaali, Christoph A. Müller, Sebastian Lucas, Jochen Scheuer, Christoph Müller, John Blanchard, Geoffrey J. Topping, Andre Wendlinger, Nadine Setzer, Sandra Sühnel, Jonas Handwerker, Christophoros Vassiliou, Frits H.A. vanHeijster, Stephan Knecht, Michael Keim, Franz Schilling, Ilai Schwartz   +23 more
doaj   +2 more sources

Intermolecular Nuclear Spin Hyperpolarization Transfer via Cross-Relaxation Triggers RASER of Solute Molecules. [PDF]

Angew Chem Int Ed Engl
Radiofrequency amplification by stimulated emission of radiation (RASER) of solutes was achieved via parahydrogen‐induced polarization (PHIP) and polarization transfer from the produced hyperpolarization donors to solutes via the intermolecular nuclear Overhauser effect (NOE).
Trofimov IA, Yi AP, Salnikov OG, Pravdivtsev AN, de Maissin H, Chekmenev EY, Hövener JB, Schmidt AB, Koptyug IV.   +8 more
europepmc   +3 more sources

Hyperpolarization of Molecular Deuterium [PDF]

Angew Chem Int Ed Engl
Hyperpolarized molecular deuterium is generated and detected using a nonhydrogenative SABRE catalyst with nicotinamide. The resonance shows a strongly enhanced partially negative line, substrate‐dependent and sensitive to transient intermediates.
Hune T, Aden A, Matz J, Moll D, Kuprov I, Glöggler S.   +5 more
europepmc   +3 more sources

Parahydrogen-induced polarization enables the single-scan NMR detection of a 236 kDa biopolymer at nanomolar concentrations

Scientific Reports, 2023
Nuclear magnetic resonance (NMR) experiments utilizing parahydrogen-induced polarization (PHIP) were performed to elucidate the PHIP activity of the synthetic 236 kDa biopolymer poly-γ-(4-propargyloxy)-benzyl-L-glutamate) (PPOBLG).
Franziska Theiss, Laura Wienands, Jonas Lins, Marcel Alcaraz-Janßen, Christina M. Thiele, Gerd Buntkowsky   +5 more
doaj   +2 more sources

Parahydrogen‐Induced Hyperpolarization of Gases

Angewandte Chemie - International Edition, 2020
AbstractImaging of gases is a major challenge for any modality including MRI. NMR and MRI signals are directly proportional to the nuclear spin density and the degree of alignment of nuclear spins with applied static magnetic field, which is called nuclear spin polarization.
Thomas Theis, Kirill Kovtunov, Eduard Chekmenev   +2 more
exaly   +4 more sources

Rapid RASER MRI. [PDF]

Angew Chem Int Ed Engl
Rapid RASER MRI allows for image acquisition without RF excitation. Instead, a population inversion on the nuclear spins is generated by SABRE hyperpolarization, which allows for self‐excitation through the RASER approach. When the desired transverse magnetization is built‐up, conventional EPI encoding is triggered to record the image.
Lehmkuhl S, Fleischer S, Yang J, Chekmenev EY, Theis T, Appelt S, Korvink JG, Jouda M.   +7 more
europepmc   +2 more sources

Parahydrogen-Based Hyperpolarization for the Masses at Millitesla Fields

Magnetochemistry
Hyperpolarization (HP) techniques, such as Parahydrogen-Induced Polarization (PHIP), Signal Amplification by Reversible Exchange (SABRE), and dissolution Dynamic Nuclear Polarization (d-DNP), significantly enhance the sensitivity of nuclear magnetic ...
Garrett L. Wibbels, Clementinah Oladun, Tanner Y. O’Hara, Isaiah Adelabu, Joshua E. Robinson, Firoz Ahmed, Zachary T. Bender, Anna Samoilenko, Joseph Gyesi, Larisa M. Kovtunova, Oleg G. Salnikov, Igor V. Koptyug, Boyd M. Goodson, W. Michael Snow, Eduard Y. Chekmenev, Roman V. Shchepin   +15 more
doaj   +2 more sources