Results 1 to 10 of about 3,524 (162)

Parahydrogen‐Based Hyperpolarization for Biomedicine

Angewandte Chemie - International Edition, 2018
AbstractMagnetic resonance (MR) is one of the most versatile and useful physical effects used for human imaging, chemical analysis, and the elucidation of molecular structures. However, its full potential is rarely used, because only a small fraction of the nuclear spin ensemble is polarized, that is, aligned with the applied static magnetic field ...
Jan-Bernd Hövener, Andrey N Pravdivtsev, Bryce Kidd   +2 more
exaly   +7 more sources

Parahydrogen‐Induced Hyperpolarization of Gases

Angewandte Chemie - International Edition, 2020
AbstractImaging of gases is a major challenge for any modality including MRI. NMR and MRI signals are directly proportional to the nuclear spin density and the degree of alignment of nuclear spins with applied static magnetic field, which is called nuclear spin polarization.
Kirill V Kovtunov, Igor V Koptyug, Marianna Fekete   +2 more
exaly   +4 more sources

A diffusion Monte Carlo study of small para-hydrogen clusters [PDF]

Open Physics, 2008
Ground state energies and chemical potentials of parahydrogen clusters are calculated from 3 to 40 molecules using the diffusion Monte Carlo technique with two different pH2-pH2 interactions.
Guardiola Rafael, Navarro Jesús
doaj   +4 more sources

Biological J‐Coupling Spectroscopy at Low Magnetic Field

Small Science
Nuclear magnetic resonance (NMR) spectroscopy is a powerful tool for investigating biological systems. In particular, low‐field NMR offers advantages for studying cellular metabolism in their native environment.
Gonzalo G. Rodriguez, Charlotte von Petersdorff‐Campen, Sergey Korchak, Oscar Sucre, Maria D. Santi, Josef Elsasser, Ruhuai Mei, Lisa M. Fries, Jan Felger, Andrea Markus, Frauke Alves, Stefan Glöggler   +11 more
doaj   +2 more sources

Advances in Parahydrogen‐Induced Polarization for Nuclear Magnetic Resonance of Peptides, Proteins, and Biopolymers

ChemistryEurope
Hyperpolarization techniques like parahydrogen‐induced polarization significantly enhance nuclear magnetic resonance (NMR) sensitivity but have been underexplored for larger biomolecules and biopolymers. Here, after a short introduction into parahydrogen‐
Gerd Buntkowsky
doaj   +2 more sources

A Controlled System for Parahydrogen Hyperpolarization Experiments

Molecules
Parahydrogen-induced hyperpolarization (PHIP), introduced nearly four decades ago, provides an elegant solution to one of the fundamental limitations of nuclear magnetic resonance (NMR)—its notoriously low sensitivity.
Lorenzo Franco, Federico Floreani, Salvatore Mamone, Ahmed Mohammed Faramawy, Marco Ruzzi, Cristina Tubaro, Gabriele Stevanato   +6 more
doaj   +4 more sources

A Versatile Compact Parahydrogen Membrane Reactor

ChemPhysChem, 2021
AbstractWe introduce a Spin Transfer Automated Reactor (STAR) that produces continuous parahydrogen induced polarization (PHIP), which is stable for hours to days. We use the PHIP variant called signal amplification by reversible exchange (SABRE), which is particularly well suited to produce continuous hyperpolarization.
Patrick TomHon, Suyong Han, Soren Lehmkuhl   +2 more
exaly   +5 more sources

High-purity solid parahydrogen [PDF]

Review of Scientific Instruments, 2021
Alkali atoms trapped in solid hydrogen matrices have demonstrated ultralong electron spin coherence times and are promising as quantum sensors. Their spin coherence is limited by magnetic noise from naturally occurring orthohydrogen molecules in the parahydrogen matrix.
Ashok Bhandari, Alexandar P. Rollings, Levi Ratto, Jonathan D. Weinstein   +3 more
openaire   +3 more sources

Parahydrogen‐Induced Polarization of Amino Acids [PDF]

Angewandte Chemie International Edition, 2021
AbstractNuclear magnetic resonance (NMR) has become a universal method for biochemical and biomedical studies, including metabolomics, proteomics, and magnetic resonance imaging (MRI). By increasing the signal of selected molecules, the hyperpolarization of nuclear spin has expanded the reach of NMR and MRI even further (e.g. hyperpolarized solid‐state
Andrey N. Pravdivtsev, Gerd Buntkowsky, Simon B. Duckett, Igor V. Koptyug, Jan‐Bernd Hövener   +4 more
openaire   +4 more sources

Efficient polarization redistribution in hyperpolarized 1-D-propane produced via pairwise parahydrogen addition

Journal of Magnetic Resonance Open, 2023
Parahydrogen-Induced Polarization (PHIP) is NMR hyperpolarization technique that has matured from fundamental science to a biomedical tool for production of hyperpolarized MRI contrast agents. The spin order of nascent parahydrogen-derived protons can be
Nuwandi M. Ariyasingha, Shiraz Nantogma, Anna Samoilenko, Oleg G. Salnikov, Nikita V. Chukanov, Larisa M. Kovtunova, Igor V. Koptyug, Eduard Y. Chekmenev   +7 more
doaj   +1 more source