Unconventional Parahydrogen-Induced Hyperpolarization Effects in Chemistry and Catalysis: From Photoreactions to Enzymes [PDF]
ACS CatalysisNuclear spin hyperpolarization utilizing parahydrogen has the potential for broad applications in chemistry, catalysis, biochemistry, and medicine.
Clifford R Bowers +2 more
exaly +2 more sources
SABRE Ir-IMes Catalysis for the Masses [PDF]
MoleculesThe Signal Amplification By Reversible Exchange (SABRE) technique provides enhancement of Nuclear Magnetic Resonance (NMR) signals up to several orders of magnitude using chemical exchange of a substrate and parahydrogen on an iridium complex. Therefore,
Izabelle Smith +13 more
doaj +2 more sources
Understanding Parahydrogen Hyperpolarized Urine Spectra: The Case of Adenosine Derivatives
Molecules, 2022 Parahydrogen hyperpolarization has emerged as a promising tool for sensitivity-enhanced NMR metabolomics. It allows resolution and quantification of NMR signals of certain classes of low-abundance metabolites that would otherwise be undetectable ...
Kerti Ausmees +2 more
doaj +2 more sources
Parahydrogen Polarization in Reverse Micelles and Application to Sensing of Protein-Ligand Binding. [PDF]
J Am Chem SocA medium containing reverse micelles supports non-hydrogenative parahydrogen induced polarization (nhPHIP) in the organic phase while solubilizing a protein in the aqueous phase.
Pham P, Biswas O, Hilty C.
europepmc +2 more sources
Parahydrogen‐Induced Polarization of a Labeled, Cancer‐Targeting DNA Aptamer
Angewandte Chemie - International Edition, 2023 Enhancing NMR signals of biomacromolecules by hyperpolarization offers exciting opportunities for diagnostic applications. However, their hyperpolarization via parahydrogen remains challenging as specific catalytic interactions are required, which are ...
Meike Emondts +2 more
exaly +2 more sources
Parahydrogen-induced polarization and spin order transfer in ethyl pyruvate at high magnetic fields
Scientific Reports, 2022 Nuclear magnetic resonance has experienced great advances in developing and translating hyperpolarization methods into procedures for fundamental and clinical studies. Here, we propose the use of a wide-bore NMR for large-scale (volume- and concentration-
Andrey N. Pravdivtsev +5 more
doaj +2 more sources
<sup>15 </sup>N Reaction Monitoring at Low and Inhomogeneous Magnetic Fields Enabled by Hyperpolarization with Parahydrogen. [PDF]
Chemistry15 N reaction monitoring at low and inhomogeneous fields enabled by PHIP. The concept was demonstrated at a magnetic field of 66 mT and 81 ppm inhomogeneity. Specifically, we measured the conversion of 15N‐boronobenzyl‐2‐styrylpyridinium to 15N‐2‐styrylpyridin.
Rodriguez GG +3 more
europepmc +2 more sources
Biological J‐Coupling Spectroscopy at Low Magnetic Field [PDF]
Small ScienceNuclear magnetic resonance (NMR) spectroscopy is a powerful tool for investigating biological systems. In particular, low‐field NMR offers advantages for studying cellular metabolism in their native environment.
Gonzalo G. Rodriguez +11 more
doaj +2 more sources
Carbon-13 Hyperpolarization of α-Ketocarboxylates with Parahydrogen in Reversible Exchange. [PDF]
ChemMedChemSignal Amplification by Reversible Exchange (SABRE) is a relatively simple and fast hyperpolarization technique that has been used to hyperpolarize the α‐ketocarboxylate pyruvate, a central metabolite and the leading hyperpolarized MRI contrast agent. In
McBride SJ +8 more
europepmc +2 more sources
StereoPHIP: Stereoselective Parahydrogen‐Induced Polarization
Angewandte Chemie - International Edition, 2023 Abstract Parahydrogen‐induced polarization (PHIP) followed by polarization transfer to 13 C is a rapidly developing technique for the generation of 13 C‐hyperpolarized substrates. Chirality plays an essential role in living systems and
Zoltan Kovacs, Mai Huynh
exaly +3 more sources