Results 11 to 20 of about 2,750 (239)
A Controlled System for Parahydrogen Hyperpolarization Experiments [PDF]
MoleculesParahydrogen-induced hyperpolarization (PHIP), introduced nearly four decades ago, provides an elegant solution to one of the fundamental limitations of nuclear magnetic resonance (NMR)—its notoriously low sensitivity.
Lorenzo Franco +6 more
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Parahydrogen‐Based Hyperpolarization for Biomedicine
Angewandte Chemie - International Edition, 2018 AbstractMagnetic resonance (MR) is one of the most versatile and useful physical effects used for human imaging, chemical analysis, and the elucidation of molecular structures. However, its full potential is rarely used, because only a small fraction of the nuclear spin ensemble is polarized, that is, aligned with the applied static magnetic field ...
Jan-Bernd Hövener +2 more
exaly +8 more sources
Biological J‐Coupling Spectroscopy at Low Magnetic Field [PDF]
Small ScienceNuclear magnetic resonance (NMR) spectroscopy is a powerful tool for investigating biological systems. In particular, low‐field NMR offers advantages for studying cellular metabolism in their native environment.
Gonzalo G. Rodriguez +11 more
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Parahydrogen‐Induced Hyperpolarization of Gases
Angewandte Chemie - International Edition, 2020 AbstractImaging of gases is a major challenge for any modality including MRI. NMR and MRI signals are directly proportional to the nuclear spin density and the degree of alignment of nuclear spins with applied static magnetic field, which is called nuclear spin polarization.
Kirill V Kovtunov +2 more
exaly +5 more sources
High-purity solid parahydrogen [PDF]
Review of Scientific Instruments, 2021 Alkali atoms trapped in solid hydrogen matrices have demonstrated ultralong electron spin coherence times and are promising as quantum sensors. Their spin coherence is limited by magnetic noise from naturally occurring orthohydrogen molecules in the parahydrogen matrix.
Ashok Bhandari +3 more
openaire +4 more sources
Advanced Science, 2023 Hyperpolarization techniques increase nuclear spin polarization by more than four orders of magnitude, enabling metabolic MRI. Even though hyperpolarization has shown clear value in clinical studies, the complexity, cost and slowness of current equipment
Luca Nagel +23 more
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Parahydrogen‐Induced Polarization of Amino Acids [PDF]
Angewandte Chemie International Edition, 2021 AbstractNuclear magnetic resonance (NMR) has become a universal method for biochemical and biomedical studies, including metabolomics, proteomics, and magnetic resonance imaging (MRI). By increasing the signal of selected molecules, the hyperpolarization of nuclear spin has expanded the reach of NMR and MRI even further (e.g. hyperpolarized solid‐state
Andrey N. Pravdivtsev +4 more
openaire +5 more sources
Reconversion of Parahydrogen Gas in Surfactant-Coated Glass NMR Tubes
Molecules, 2023 The application of parahydrogen gas to enhance the magnetic resonance signals of a diversity of chemical species has increased substantially in the last decade.
Robert V. Chimenti +4 more
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Scientific Reports, 2023 Nuclear magnetic resonance (NMR) experiments utilizing parahydrogen-induced polarization (PHIP) were performed to elucidate the PHIP activity of the synthetic 236 kDa biopolymer poly-γ-(4-propargyloxy)-benzyl-L-glutamate) (PPOBLG).
Franziska Theiss +5 more
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Understanding Parahydrogen Hyperpolarized Urine Spectra: The Case of Adenosine Derivatives
Molecules, 2022 Parahydrogen hyperpolarization has emerged as a promising tool for sensitivity-enhanced NMR metabolomics. It allows resolution and quantification of NMR signals of certain classes of low-abundance metabolites that would otherwise be undetectable ...
Kerti Ausmees +2 more
doaj +2 more sources