Results 31 to 40 of about 51,213 (265)

Hyperpolarized Dihydroxyacetone Is a Sensitive Probe of Hepatic Gluconeogenic State

Metabolites, 2021
Type II diabetes and pre-diabetes are widely prevalent among adults. Elevated serum glucose levels are commonly treated by targeting hepatic gluconeogenesis for downregulation. However, direct measurement of hepatic gluconeogenic capacity is accomplished
Mukundan Ragavan, Marc A. McLeod, Anthony G. Giacalone, Matthew E. Merritt   +3 more
doaj   +1 more source

NMR Hyperpolarization Techniques of Gases [PDF]

Chemistry – A European Journal, 2016
AbstractInvited for the cover of this issue is a group of researchers coordinated by E. Y. Chekmenev from Vanderbilt University. The image depicts hyperpolarized Xe‐129 and parahydrogen gases and their MRI applications. Read the full text of the article at 10.1002/chem.201603884.
Danila A. Barskiy, Aaron M. Coffey, Panayiotis Nikolaou, Dmitry M. Mikhaylov, Boyd M. Goodson, Rosa T. Branca, George J. Lu, Mikhail G. Shapiro, Ville‐Veikko Telkki, Vladimir V. Zhivonitko, Igor V. Koptyug, Oleg G. Salnikov, Kirill V. Kovtunov, Valerii I. Bukhtiyarov, Matthew S. Rosen, Michael J. Barlow, Shahideh Safavi, Ian P. Hall, Leif Schröder, Eduard Y. Chekmenev   +19 more
openaire   +5 more sources

Hyperpolarizing DNA Nucleobases via NMR Signal Amplification by Reversible Exchange

Molecules, 2023
The present work investigates the potential for enhancing the NMR signals of DNA nucleobases by parahydrogen-based hyperpolarization. Signal amplification by reversible exchange (SABRE) and SABRE in Shield Enables Alignment Transfer to Heteronuclei ...
Bryce E. Kidd, Max E. Gemeinhardt, Jamil A. Mashni, Jonathan L. Gesiorski, Liana B. Bales, Miranda N. Limbach, Roman V. Shchepin, Kirill V. Kovtunov, Igor V. Koptyug, Eduard Y. Chekmenev, Boyd M. Goodson   +10 more
doaj   +1 more source

Developing hyperpolarized metabolic contrast agents at high field dDNP for large animal research

Journal of Magnetic Resonance Open
Dissolution Dynamic Nuclear Polarization (dDNP) polarizers have achieved high field strengths and large sample volumes. These advancements necessitate new formulations of hyperpolarized metabolic contrast agents (HMCAs) to enable large animal studies ...
Ditte B. Christensen, Ingeborg S. Skre, Jan Henrik Ardenkjær-Larsen, Magnus Karlsson, Mathilde H. Lerche   +4 more
doaj   +1 more source

Reversible Parahydrogen Induced Hyperpolarization of 15N in Unmodified Amino Acids Unraveled at High Magnetic Field

Advanced Science, 2023
Amino acids (AAs) and ammonia are metabolic markers essential for nitrogen metabolism and cell regulation in both plants and humans. NMR provides interesting opportunities to investigate these metabolic pathways, yet lacks sensitivity, especially in case
Ewoud Vaneeckhaute, Jean‐Max Tyburn, James G. Kempf, Johan A. Martens, Eric Breynaert   +4 more
doaj   +1 more source

Vasodilation by Hyperpolarization [PDF]

Hypertension, 2006
Clinical assessment of human vascular endothelial function in vivo involves use of specific antagonists such as l-N G monomethyl arginine (l-NMMA) and cyclooxygenase inhibition to establish the contribution of NO and prostaglandins, respectively, to either resting vascular tone, agonist-stimulated vasodilation, or physiological and metabolic ...
Arshed A. Quyyumi, Muhiddin Ozkor
openaire   +1 more source

Interfacing Liquid State Hyperpolarization Methods with NMR Instrumentation

Journal of Magnetic Resonance Open, 2022
Advances in liquid state hyperpolarization methods have enabled new applications of high-resolution NMR spectroscopy. Utilizing strong signal enhancements from hyperpolarization allows performing NMR spectroscopy at low concentration, or with high time ...
Pierce Pham, Ratnamala Mandal, Chang Qi, Christian Hilty   +3 more
doaj   +1 more source

Synthetic Studies Toward ［1-13C］Pyruvate

Journal of Isotopes, 2023
Magnetic resonance imaging (MRI) is limited in clinical application due to its low sensitivity. Hyperpolarization technology overcomes this limitation by enhancing molecular MRI signal.
QING Jing;JIA Xuelei;CHEN Kai;DAI Desheng;LI Guowei
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Hyperpolarization Methods for MRS [PDF]

, 2015
© 2015 John Wiley & Sons, Ltd. This article covers the fundamental principles and practice of NMR hyperpolarization techniques, which are proving useful for in vivo magnetic resonance spectroscopy (MRS) studies of metabolism in animal models, and clinical trials with hyper-enhanced sensitivity.
Goodson, Boyd M., Whiting, Nicholas, Coffey, Aaron M., Nikolaou, Panayiotis, Shi, Fan, Gust, Brogan M., Gemeinhardt, Max E., Shchepin, Roman V., Skinner, Jason G., Birchall, Jonathan R., Barlow, Michael J., Chekmenev, Eduard Y.   +11 more
openaire   +1 more source