Results 51 to 60 of about 88,078 (299)
Interfacing Liquid State Hyperpolarization Methods with NMR Instrumentation
Journal of Magnetic Resonance Open, 2022 Advances in liquid state hyperpolarization methods have enabled new applications of high-resolution NMR spectroscopy. Utilizing strong signal enhancements from hyperpolarization allows performing NMR spectroscopy at low concentration, or with high time ...
Pierce Pham +3 more
doaj +1 more source
Cellular mechanisms of potassium homeostasis in the mammalian nervous system [PDF]
, 1987 Double-barrelled ion-sensitive microelectrodes were used to measure changes in the intracellular activities of K+, Na+, and Cl- (aKi, aNai, aCli) in neurones of rat sympathetic ganglia and in glial cells of slices from guinea-pig olfactory cortex.
Ballanyi, Klaus, Grafe, Peter
core +1 more source
Synthetic Studies Toward ［1-13C］Pyruvate
Journal of Isotopes, 2023 Magnetic resonance imaging (MRI) is limited in clinical application due to its low sensitivity. Hyperpolarization technology overcomes this limitation by enhancing molecular MRI signal.
QING Jing;JIA Xuelei;CHEN Kai;DAI Desheng;LI Guowei
doaj +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Journal of Biological Dynamics, 2021 The dynamic mechanism of a whole-cell model containing electrical signalling and two-compartment Ca $ ^{2+} $ signalling in gonadotrophs is investigated.
Xiaowen Xiong, Yanqiu Li, Dongmei Zheng
doaj +1 more source
Study of the properties of hyperpolarized xenon-129 for magnetic resonance imaging [PDF]
, 2009 Produkce hyperpolarizovaných plynů, především helia (3He) nebo xenonu (129Xe), nachází stále rostoucí rozsah aplikací v zobrazování magnetickou rezonancí (MRI).
Rychnovský, Jan
core
EPSPs in rat neocortical neurons in vitro. II. Involvement of N-methyl-D-aspartate receptors in the generation of EPSPs [PDF]
, 1989 1. Intracellular recordings were obtained from neurons in layer II/III of rat frontal cortex. Single-electrode current- and voltage-clamp techniques were employed to compare the sensitivity of excitatory postsynaptic potentials (EPSPs) and ...
Hablitz, John H., Sutor, Bernd
core +1 more source
Toward C13 hyperpolarized biomarkers produced by thermal mixing with hyperpolarized X129e [PDF]
The Journal of Chemical Physics, 2009 The C13 NMR signal of acetic acid 1-C13-AcH is enhanced by polarization transfer from hyperpolarized X129e using a thermal mixing procedure. 1-C13-AcH acid and hyperpolarized X129e are mixed as gases to disperse X129e in the acetic acid. The mixture is frozen with liquid N2 at 0.5 T.
Natalia, Lisitza +5 more
openaire +2 more sources
Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz +3 more
wiley +1 more source
Efflux pumps mediate changes to fundamental bacterial physiology via membrane potential
mBioEfflux pumps are well known to be an important mechanism for removing noxious substances such as antibiotics from bacteria. Given that many antibiotics function by accumulating inside bacteria, efflux pumps contribute to resistance.
Emily E. Whittle +6 more
doaj +1 more source