Results 61 to 70 of about 51,213 (265)

Wearable Electro‐Thermal Haptic Stimulator Driven by a Self‐Powered Tactile Sensor for Realistic Stimulus Replication

Advanced Science, EarlyView.
We present a stimulus‐replicating system combining a tactile sensor with a wearable Peltier thermotactile module and concentric electrotactile electrode. Signals encoding pressure and temperature drive the stimulators to reproduce mechano‐thermal cues on the skin. AlN/PDMS encapsulation and SA/LA PSA ensure mechanical compliance and thermal efficiency.
Ey‐In Lee, Chae‐Young Kang, Kyuhyun Hwang, Jongbaeg Kim, Jin‐Woo Park   +4 more
wiley   +1 more source

Cardiac pH-Imaging With Hyperpolarized MRI

Frontiers in Cardiovascular Medicine, 2020
Regardless of the importance of acid-base disturbances in cardiac disease, there are currently no methods for clinical detection of pH in the heart. Several magnetic resonance imaging techniques hold translational promise and may enable in-vivo mapping ...
Nikolaj Bøgh, Esben Søvsø Szocska Hansen, Christian Østergaard Mariager, Lotte Bonde Bertelsen, Steffen Ringgaard, Christoffer Laustsen   +5 more
doaj   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

A Controlled System for Parahydrogen Hyperpolarization Experiments

Molecules
Parahydrogen-induced hyperpolarization (PHIP), introduced nearly four decades ago, provides an elegant solution to one of the fundamental limitations of nuclear magnetic resonance (NMR)—its notoriously low sensitivity.
Lorenzo Franco, Federico Floreani, Salvatore Mamone, Ahmed Mohammed Faramawy, Marco Ruzzi, Cristina Tubaro, Gabriele Stevanato   +6 more
doaj   +1 more source

Hyperpolarization of Nitrile Compounds Using Signal Amplification by Reversible Exchange

Molecules, 2020
Signal Amplification by Reversible Exchange (SABRE), a hyperpolarization technique, has been harnessed as a powerful tool to achieve useful hyperpolarized materials by polarization transfer from parahydrogen.
Sarah Kim, Sein Min, Heelim Chae, Hye Jin Jeong, Sung Keon Namgoong, Sangwon Oh, Keunhong Jeong   +6 more
doaj   +1 more source

Human Foetal Neuroblasts Exhibit BK Channel‐Dependent Membrane Voltage Oscillations upon Depolarization

Advanced Science, EarlyView.
Primary cultures of neuroblasts isolated from the nucleus basalis of Meynert of 12‐weeks‐old human foetuses were prepared. Whole‐cell patch‐clamp recordings were performed by injecting a depolarizing stimulus current (+500 pA; 500 ms), and the membrane voltage recorded; this stimulus current evoked periodic‐like oscillations in membrane voltage ...
Elisabetta Coppi, Federica Cherchi, Martina Venturini, Federico Tommasi, Sandro Gonzi, Chiara Capacci, Giulia Guarnieri, Pasquale Gallina, Annamaria Morelli, Anna Maria Pugliese   +9 more
wiley   +1 more source

Different flavors of diffusion in paramagnetic systems: Unexpected NMR signal intensity and relaxation enhancements

Journal of Magnetic Resonance Open, 2020
The NMR community is well acquainted with different kinds of diffusion but, at the same time, there are several effects that are worth a better understanding for an improved design of molecular imaging and dynamic nuclear polarization experiments.
Enrico Ravera, Marco Fragai, Giacomo Parigi, Claudio Luchinat   +3 more
doaj   +1 more source

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Integration of Redox‐Active Polyoxovanadate Clusters into PMMA: Structure, Nanoscale Organization and Multilevel Redox Switching

Advanced Electronic Materials, EarlyView.
Solvent‐processable polyoxovanadate–PMMA nanocomposites exhibit concentration‐dependent 2D and 3D organization on gold surfaces, while retaining multilevel redox switching at room temperature. These hybrids bridge nanoscale functionality and macroscopic measurement, establishing a versatile platform for hybrid molecular–polymer memory materials ...
Jonas Lorenz, Marco Moors, Tom Scherzer, Olesya Daikos, Jens Bauer, Andrea Prager, Jan Griebel, Yeji Lee, Vineeth Kumar Bandari, Thomas Blaudeck, Oliver G. Schmidt, Kirill Monakhov   +11 more
wiley   +1 more source

Assessing Therapeutic Efficacy in Real-time by Hyperpolarized Magnetic Resonance Metabolic Imaging

Cells, 2019
Precisely measuring tumor-associated alterations in metabolism clinically will enable the efficient assessment of therapeutic responses. Advances in imaging technologies can exploit the differences in cancer-associated cell metabolism as compared to ...
Prasanta Dutta, Travis C. Salzillo, Shivanand Pudakalakatti, Seth T. Gammon, Benny A. Kaipparettu, Florencia McAllister, Shawn Wagner, Daniel E. Frigo, Christopher J. Logothetis, Niki M. Zacharias, Pratip K. Bhattacharya   +10 more
doaj   +1 more source