Results 71 to 80 of about 51,213 (265)

Parametric Analysis of Spiking Neurons in 16 nm Fin Field‐Effect Transistor Technology

Advanced Intelligent Discovery, EarlyView.
Energy efficient computing has driven a shift toward brain‐inspired neuromorphic hardware. This study explores the design of three distinct silicon neuron topologies implemented in 16 nm fin field‐Effect transistor technology. While the Axon‐Hillock design achieves gigahertz throughput, its functional fragility persists. The Morris–Lecar model captures
Logan Larsh, Raiyan Siddique, Sarah S. Sharif, Yaser Mike Banad   +3 more
wiley   +1 more source

Ac‐SDKP modulates apoptosis via HSP27 and the FAS/FASL and mitochondrial axes

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of Ac‐SDKP regulating the FAS/FASL and mitochondrial apoptosis pathways via HSP27. Ac‐SDKP inhibits HSP27 expression, activates the FAS/FASL pathway and Caspase‐3 signaling, increases Caspase‐8 and Caspase‐3 expression, and induces cell apoptosis.
Wenxin Guo, Jinyin Yan, Wenli Li, Jin Wang, Lu Liu, Chengmei Zhang, Wei Cao, Shanshan Yao, Haibo Gong, Yi He, Zihan Zhou, Siyan Chen, Li Feng, Haijing Deng   +13 more
wiley   +1 more source

Biological J‐Coupling Spectroscopy at Low Magnetic Field

Small Science
Nuclear magnetic resonance (NMR) spectroscopy is a powerful tool for investigating biological systems. In particular, low‐field NMR offers advantages for studying cellular metabolism in their native environment.
Gonzalo G. Rodriguez, Charlotte von Petersdorff‐Campen, Sergey Korchak, Oscar Sucre, Maria D. Santi, Josef Elsasser, Ruhuai Mei, Lisa M. Fries, Jan Felger, Andrea Markus, Frauke Alves, Stefan Glöggler   +11 more
doaj   +1 more source

Minute‐Scale Repeated Metabolic Probing of Living Cells Enabled by Rapid Parahydrogen‐Based Hyperpolarization

Angewandte Chemie International Edition, EarlyView.
Rapid parahydrogen hyperpolarization combined with simple dilution enables biocompatible delivery of hyperpolarized pyruvate to immobilized living cells within ≈1 min. Repeated substrate injections reveal frequency‐dependent metabolic dynamics, introducing a new temporal dimension for hyperpolarized NMR studies of cellular metabolism and enabling rapid
Philipp R. Groß, Stefan Petersen, Zirun Wang, Behnam Shamshiri, Henri de Maissin, Sebastian Lucas, Oliver Gorka, Lisa Heß, Irene Marco‐Rius, Lluís Mangas‐Florencio, André F. Martins, Philipp Boehm‐Sturm, Maxim Zaitsev, Robert Zeiser, Jan‐Bernd Hövener, Thomas Reinheckel, Olaf Groß, Andreas B. Schmidt   +17 more
wiley   +1 more source

Interaction of the Gut Microbiota and the Enteric Nervous System: Implications in Gastrointestinal Disorders Associated With Autism Spectrum Disorder

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction, restricted interests, and repetitive behaviors. In addition to these core behavioral symptoms, gastrointestinal (GI) disorders are frequently reported, ranging from severe constipation to diarrhea.
Baptiste Ganachaud, María José Mendoza‐León, Justine Marchix, Alonso Fernandez Tello, Catherine Le Berre Scoul, Ma Cecilia Opazo, Michel Neunlist, Claudia A. Riedel, Martial Caillaud, Hélène Boudin   +9 more
wiley   +1 more source

Membrane potential hyperpolarization: a critical factor in acrosomal exocytosis and fertilization in sperm within the female reproductive tract

Frontiers in Cell and Developmental Biology
Hyperpolarization of the membrane potential (Em), a phenomenon regulated by SLO3 channels, stands as a central feature in sperm capacitation—a crucial process conferring upon sperm the ability to fertilize the oocyte.
Paula A. Balestrini, Valeria Sulzyk, Martina Jabloñski, Liza J. Schiavi-Ehrenhaus, Soledad N. González, Juan J. Ferreira, Matías D. Gómez-Elías, Pablo Pomata, Guillermina M. Luque, Dario Krapf, Patricia S. Cuasnicu, Celia M. Santi, Mariano G. Buffone   +12 more
doaj   +1 more source

Hyperpolarized Laplace NMR [PDF]

Magnetic Resonance in Chemistry, 2018
Laplace nuclear magnetic resonance (NMR), dealing with NMR relaxation and diffusion experiments, reveals details of molecular motion and provides chemical resolution complementary to NMR spectra. Laplace NMR has witnessed a great progress in past decades due to the development of methodology and signal processing, and it has lots of extremely ...
openaire   +3 more sources

Gabapentinoids‐duloxetine combination therapy for chronic pain: A mechanism oriented rational to bridge theoretical knowledge and real life setting

British Journal of Clinical Pharmacology, EarlyView.
Chronic pain represents a complex debilitating condition that extends beyond the protective function of physiological pain, often persisting as an independent disease entity. Chronic primary and secondary pain syndromes reflect a multifaceted continuum involving nociceptive, neuropathic and nociplastic mechanisms.
Stefania Nobili, Maurizio Evangelista, Elena Lucarini, Elena G. Giugliano, Carla Ghelardini, Laura Micheli, Lorenzo Di Cesare Mannelli   +6 more
wiley   +1 more source

Comparative Study of Gas and Liquid Flow in Packed Beds Using Phase‐Contrast MRI

Chemie Ingenieur Technik, EarlyView.
This work presents applications of phase‐contrast magnetic resonance imaging (MRI) to investigate fluid flow fields and temperature in packed beds. Comparison of ethane (C2H6) gas flow with that of water flow is done at similar flow conditions. The temperature of water is also measured using MRI.
Maitreyi Sangal, Maria Anikeeva, Frank Godenschweger, Jan‐Bernd Hövener, Oliver Speck   +4 more
wiley   +1 more source

From Olefin Coordination to Rh─N Bond Formation and Oxidative Addition: pH Effects in Rhodium α‐Methyl‐β‐Amidoitaconate Complexes

European Journal of Inorganic Chemistry, EarlyView.
The coordination of α‐methyl‐β‐amidoitaconate at Rh(I) diphosphine complexes is studied using a combination of high‐field and low‐field flow NMR spectroscopy and X‐ray analysis. In the presence of basic or acidic additives, the formation of neutral Rh(I) or Rh(III) complexes occurs.
Neeraja M. Kaimal, Thomas Osterland, Hans‐Joachim Drexler, Torsten Beweries   +3 more
wiley   +1 more source