Results 91 to 100 of about 88,078 (299)

Different flavors of diffusion in paramagnetic systems: Unexpected NMR signal intensity and relaxation enhancements

Journal of Magnetic Resonance Open, 2020
The NMR community is well acquainted with different kinds of diffusion but, at the same time, there are several effects that are worth a better understanding for an improved design of molecular imaging and dynamic nuclear polarization experiments.
Enrico Ravera, Marco Fragai, Giacomo Parigi, Claudio Luchinat   +3 more
doaj   +1 more source

Effects of methamphetamine on locomotor activity and thalamic gene expression in leptin-deficient obese mice [PDF]

, 2017
Leptin is an adipose-derived hormone that regulates energy balance. Leptin receptors are expressed in extrahypothalamic sites and several reports showed that leptin can influence feeding and locomotor behavior via direct actions on dopaminergic neurons ...
Bisagno, Veronica, Gonzalez, Betina, Gonzalez, Candela Rocio, Urbano Suarez, Francisco Jose   +3 more
core   +2 more sources

Parametric Analysis of Spiking Neurons in 16 nm Fin Field‐Effect Transistor Technology

Advanced Intelligent Discovery, EarlyView.
Energy efficient computing has driven a shift toward brain‐inspired neuromorphic hardware. This study explores the design of three distinct silicon neuron topologies implemented in 16 nm fin field‐Effect transistor technology. While the Axon‐Hillock design achieves gigahertz throughput, its functional fragility persists. The Morris–Lecar model captures
Logan Larsh, Raiyan Siddique, Sarah S. Sharif, Yaser Mike Banad   +3 more
wiley   +1 more source

Assessing Therapeutic Efficacy in Real-time by Hyperpolarized Magnetic Resonance Metabolic Imaging

Cells, 2019
Precisely measuring tumor-associated alterations in metabolism clinically will enable the efficient assessment of therapeutic responses. Advances in imaging technologies can exploit the differences in cancer-associated cell metabolism as compared to ...
Prasanta Dutta, Travis C. Salzillo, Shivanand Pudakalakatti, Seth T. Gammon, Benny A. Kaipparettu, Florencia McAllister, Shawn Wagner, Daniel E. Frigo, Christopher J. Logothetis, Niki M. Zacharias, Pratip K. Bhattacharya   +10 more
doaj   +1 more source

Hyperpolarized Laplace NMR [PDF]

Magnetic Resonance in Chemistry, 2018
Laplace nuclear magnetic resonance (NMR), dealing with NMR relaxation and diffusion experiments, reveals details of molecular motion and provides chemical resolution complementary to NMR spectra. Laplace NMR has witnessed a great progress in past decades due to the development of methodology and signal processing, and it has lots of extremely ...
openaire   +3 more sources

Astrocytic Mitochondria Transplantation Rescues Neuron Loss and Dendritic Injuries in Acute Cerebral Ischemic Stroke Mouse Model by Flexibly Regulating Mitochondria Dynamics

Annals of Neurology, EarlyView.
Objective Cerebral ischemic stroke causes neuronal oxygen/energy deprivation, disrupting mitochondrial function including reduced membrane potential and bioenergetics, exacerbating neuronal injury. Mitochondrial defects are, therefore, a central neuropathological node and potential therapeutic target.
Ning Bian, Jianing Shen, Linwei Tian, Jinghui Li, Lu Yang, Bo Yuan, Shulin Li, Yuyu Niu, Lu Zhao, Jingkuan Wei   +9 more
wiley   +1 more source

A low-voltage activated, transient calcium current is responsible for the time-dependent depolarizing inward rectification of rat neocortical neurons in vitro [PDF]

, 1987
Intracellular recordings were obtained from rat neocortical neurons in vitro. The current-voltage-relationship of the neuronal membrane was investigated using current- and single-electrode-voltage-clamp techniques.
A Constanti, A Constanti, A Finkelstein, BA Vogt, Bernd Sutor, BW Connors, CE Stafstrom, CE Stafstrom, CE Stafstrom, CE Stafstrom, D Johnston, DA McCormick, E Carbone, F Crepel, H Jahnsen, H Jahnsen, H Jahnsen, H Jahnsen, JR Hotson, JR Howe, JR Howe, JV Halliwell, K Murase, ML Mayer, P Adams, P Franz, P Schwindt, PG Nelson, R Llin�s, R Llin�s, R Llin�s, R Llin�s, RJ Docherty, S Hagiwara, SA Fedulova, W Rall, W Rall, Walter Zieglg�nsberger   +37 more
core   +1 more source

Towards hyperpolarization of oil molecules via nitrogen-vacancy centers in diamond

, 2017
Efficient polarization of organic molecules is of extraordinary relevance when performing nuclear magnetic resonance (NMR) and imaging. Commercially available routes to dynamical nuclear polarization (DNP) work at extremely low-temperatures, thus ...
Chen, Q., Fernández-Acebal, P., Jelezko, F., McGuinness, L. P., Müller, C., Müller, S., Naydenov, B., Plenio, M. B., Retzker, A., Rosolio, O., Scheuer, J., Schmitt, S., Schwarz, I.   +12 more
core   +1 more source

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

British Journal of Clinical Pharmacology, EarlyView.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić, Patrick Eustaquio, Elvira Meni Maria Gkrinia, Ivana Stević, Eugen Javor, Yun Wah Lam, Slobodan Janković, Dinko Vitezić   +7 more
wiley   +1 more source

Biological J‐Coupling Spectroscopy at Low Magnetic Field

Small Science
Nuclear magnetic resonance (NMR) spectroscopy is a powerful tool for investigating biological systems. In particular, low‐field NMR offers advantages for studying cellular metabolism in their native environment.
Gonzalo G. Rodriguez, Charlotte von Petersdorff‐Campen, Sergey Korchak, Oscar Sucre, Maria D. Santi, Josef Elsasser, Ruhuai Mei, Lisa M. Fries, Jan Felger, Andrea Markus, Frauke Alves, Stefan Glöggler   +11 more
doaj   +1 more source