Results 91 to 100 of about 61,022 (308)
Journal of Magnetic Resonance Open, 2020 The NMR community is well acquainted with different kinds of diffusion but, at the same time, there are several effects that are worth a better understanding for an improved design of molecular imaging and dynamic nuclear polarization experiments.
Enrico Ravera +3 more
doaj +1 more source
Assessing Therapeutic Efficacy in Real-time by Hyperpolarized Magnetic Resonance Metabolic Imaging
Cells, 2019 Precisely measuring tumor-associated alterations in metabolism clinically will enable the efficient assessment of therapeutic responses. Advances in imaging technologies can exploit the differences in cancer-associated cell metabolism as compared to ...
Prasanta Dutta +10 more
doaj +1 more source
Hyperpolarized
Magnetic Resonance in Chemistry, 2018 Laplace nuclear magnetic resonance (NMR), dealing with NMR relaxation and diffusion experiments, reveals details of molecular motion and provides chemical resolution complementary to NMR spectra. Laplace NMR has witnessed a great progress in past decades due to the development of methodology and signal processing, and it has lots of extremely ...
openaire +3 more sources
Insulin-induced hyperpolarization in mammalian skeletal muscle
, 1989 Insulin-induced hyperpolarization of up to 9 mV has been described in isolated frog [J. Physiol. Lond. 252: 43-58, 1975; Am. J. Physiol. 251 (Cell Physiol.
N. Sperelakis +3 more
core +1 more source
Epilepsia, EarlyView.Abstract Objective Neonatal developmental and epileptic encephalopathy with movement disorder and arthrogryposis (NDEEMA) represents the most severe end of the gain‐of‐function (GOF) SCN1A disorder spectrum. Sporadic cases of congenital arthrogryposis have also been reported in individuals with SCN2A‐, SCN3A‐, and SCN8A‐related developmental and ...
Sopio Gverdtsiteli +43 more
wiley +1 more source
Cardiac remodeling and arrhythmia in a mouse model of Depdc5 haploinsufficiency
Epilepsia, EarlyView.Abstract Objective Some ion channel genes linked to developmental and epileptic encephalopathy (DEE) are also linked to cardiac arrhythmia, leading to the hypothesis that predisposition to cardiac arrhythmias may contribute to the complex disease presentation of DEE and possibly to the mechanism of sudden unexpected death in epilepsy.
Roberto Ramos‐Mondragon +9 more
wiley +1 more source
An n‐of‐1 gene‐directed drug repurposing trial for an ultrarare genetic condition
Epilepsia, EarlyView.Abstract Objective Gain‐of‐function (GoF) variants in the KCNC1 potassium channel subunit gene (Kv3.1) cause motor/cognitive delays and hypotonia and have been associated with seizures. Fluoxetine has inhibitory effects on Kv3.1. However, open‐label nonrandomized administration is insufficient to guide clinical decision‐making in ultrarare conditions ...
Vedika Jha +13 more
wiley +1 more source
Biological J‐Coupling Spectroscopy at Low Magnetic Field
Small ScienceNuclear magnetic resonance (NMR) spectroscopy is a powerful tool for investigating biological systems. In particular, low‐field NMR offers advantages for studying cellular metabolism in their native environment.
Gonzalo G. Rodriguez +11 more
doaj +1 more source
WONOEP XVII appraisal: The role of the extracellular matrix in epilepsy
Epilepsia, EarlyView.Abstract The extracellular matrix (ECM) is composed of proteoglycans and glycoproteins that regulate the external environment surrounding neurons, glia, and the vascular system. The ECM is vital for maintaining the structure and function of the brain and also acts as a reservoir for various signaling molecules and neurotransmitters, modulating synaptic
Eleonora Lugara +7 more
wiley +1 more source
Reduced after-hyperpolarization in cultured Gabra5−/− neurons.
, 2013 A) Action potentials were elicited in WT and Gabra5−/− neurons at a frequency of 5 Hz (examples shown in upper traces). The membrane hyperpolarization that occurred following depolarization was measured relative to resting membrane potential to reveal a ...
Agnieszka A. Zurek (389429) +4 more
core +1 more source