Results 101 to 110 of about 61,022 (308)

Methods based on hyperpolarization and flow for enhanced Magnetic Resonance

, 2022
International audienceCompared with other analytical or imaging techniques, nuclear magnetic resonance (NMR) is a modality with an inherently low sensitivity, regardless of which spectroscopy (magnetic resonance spectroscopy, MRS) or imaging (magnetic ...
Berthault, Patrick, Huber, Gaspard
core   +1 more source

Modeling temporal lobe epilepsy with hippocampal sclerosis in rats using the selective neurotoxin stable substance P‐saporin

Epilepsia, EarlyView.
On day 0 adult male and female rats were injected with Stable Substance P‐Saporin (SSP‐SAP) at 4 unilateral sites along the longitudinal axis of the dentate gyrus. Rats exhibited spontaneous electrographic and behavioral reactive seizures between days 4‐6. There was a progressive loss of CA1 and CA3 neurons and a progressive increase in astrocytes over
Srijal Gupta, Mitchell T. Kesler, Morris H. Scantlebury, Robert S. Sloviter, G. Campbell Teskey   +4 more
wiley   +1 more source

Compensatory rearrangement of parvalbumin interneuron voltage‐gated sodium channel subunits in a mouse model of Dravet syndrome

Epilepsia, EarlyView.
Abstract Heterozygous loss‐of‐function variants in the gene SCN1A, which encodes the voltage‐gated sodium channel (VGSC) pore‐forming (α) subunit NaV1.1, lead to a spectrum of neurological disease, including Dravet syndrome. NaV1.1 is prominently expressed at the proximal portion of the axon initial segment (AIS) of fast‐spiking γ‐aminobutyric ...
Ania K. Dabrowski, Ala Somarowthu, Sophie R. Liebergall, Damaris N. Lorenzo, Ethan M. Goldberg   +4 more
wiley   +1 more source

Membrane potential hyperpolarization: a critical factor in acrosomal exocytosis and fertilization in sperm within the female reproductive tract

Frontiers in Cell and Developmental Biology
Hyperpolarization of the membrane potential (Em), a phenomenon regulated by SLO3 channels, stands as a central feature in sperm capacitation—a crucial process conferring upon sperm the ability to fertilize the oocyte.
Paula A. Balestrini, Valeria Sulzyk, Martina Jabloñski, Liza J. Schiavi-Ehrenhaus, Soledad N. González, Juan J. Ferreira, Matías D. Gómez-Elías, Pablo Pomata, Guillermina M. Luque, Dario Krapf, Patricia S. Cuasnicu, Celia M. Santi, Mariano G. Buffone   +12 more
doaj   +1 more source

Anterior cingulate cortex neuron subtypes differentially regulate seizures

Epilepsia, EarlyView.
Abstract Objective This study aimed to investigate the regulatory roles of distinct neuronal subtypes within the anterior cingulate cortex (ACC) in acute seizures and to identify cell type‐specific mechanisms underlying seizure modulation in this region. Methods Acute seizure models were established in mice via pentylenetetrazol injection.
Ziqian Yan, Ting Tang, Kaishan Wang, Bin Fu, Zesheng Li, Mingshan Liu, Hongyi Huang, Yanfeng Yang, Qiang Zheng, Yangmin Zheng, Yongzhi Shan, Yumin Luo, Guoguang Zhao   +12 more
wiley   +1 more source

Hyperpolarization using Parahydrogen [PDF]

, 2013
Work presented in the thesis encompasses the hyperpolarization techniques, SABRE and PHIP, within the context of nuclear magnetic resonance spectroscopy. In the first instance, pyridine derivatives have been hyperpolarized using [Ir(COD)(IMe)Cl].
Khan, Majid
core  

Cardiovascular Applications of Hyperpolarized MRI [PDF]

Current Cardiovascular Imaging Reports, 2011
Many applications of MRI are limited by an inherently low sensitivity. Previous attempts to overcome this insensitivity have focused on the use of MRI systems with stronger magnetic fields. However, the gains that can be achieved in this way are relatively small and increasing the magnetic field invariably leads to greater technical challenges.
openaire   +3 more sources

Lipid‐based Nano‐delivery systems as a promising strategy for the treatment of epilepsy: Current status and challenges

Epilepsia Open, EarlyView.
Abstract Objective Epilepsy is a prevalent chronic neurological disorder characterized by abnormal neuronal electrical activity. The primary treatment modality for individuals with epilepsy (PWE) is antiseizure medication (ASM). The multiple potential factors contributing to treatment resistance in epilepsy may be attributed to the inability of ASMs to
Priya Kannan Varshini, Arunachalam Divya, Kumar Sowndharya, Parthiban Jeevitha, Selvam Manoj, Ashiq Rahman, Athil Ahamed, Ravichandiran Abirahul, Paranthaman Subash, Sulekha Khute   +9 more
wiley   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Hyperpolarization - Description, Overview & Method

, 2017
Hyperpolarization: What does it mean? Dissolution Dynamic Nuclear Polarization (dDNP) Spin Exchange Optical pumping Para-hydrogen induced polarization (PHIP, SABRE) Imaging Methods: RF pulse strategies Acquisition strategies Analysis – kinetic
Larson, Peder Eric Zufall
core   +1 more source