Results 121 to 130 of about 88,078 (299)

Ultrasensitive 129Xe Magnetic Resonance Imaging: From Clinical Monitoring to Molecular Sensing

Advanced Science
Magnetic resonance imaging (MRI) is a cornerstone technology in clinical diagnostics and in vivo research, offering unparalleled visualization capabilities.
Yuqi Yang, Sen Yue, Luyang Shen, Huiling Dong, Haidong Li, Xiuchao Zhao, Qianni Guo, Xin Zhou   +7 more
doaj   +1 more source

The Role and Therapeutic Potential of Voltage‐Gated Potassium Channel Kv1.3 in Metabolism‐Related Disorders

iNew Medicine, EarlyView.
ABSTRACT Over the past three decades, the global burden of common metabolic diseases such as obesity, diabetes, and atherosclerosis has steadily increased, becoming a serious public health issue that poses a major threat to human health worldwide. Potassium channels, particularly the voltage‐gated Kv1.3 subtype, serve as critical regulators of cellular
Wenjun Zhen, Junda Liu, Xixi Chen, Shi Chen, Yuanyuan Tian, Baoming Wu, Fengxia Yan   +6 more
wiley   +1 more source

Over 50 % 1H and 13C Polarization for Generating Hyperpolarized Metabolites—A para‐Hydrogen Approach

ChemistryOpen, 2018
para‐Hydrogen‐induced polarization (PHIP) is a method to rapidly generate hyperpolarized compounds, enhancing the signal of nuclear magnetic resonance (NMR) experiments by several thousand‐fold.
Dr. Sergey Korchak, Dr. Salvatore Mamone, Dr. Stefan Glöggler   +2 more
doaj   +1 more source

Benchmarking Hybrid CNN‐Transformer Versus Pure Transformer Architectures for Accelerated Hyperpolarized 129Xe MRI Reconstruction

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Hyperpolarized 129Xe MRI faces technical challenges including low signal‐to‐noise ratio and breath‐hold constraints. Current literature focuses on proprietary deep learning methods or image‐domain enhancements. Purpose To present a comprehensive evaluation of transformer and hybrid CNN‐transformer architectures integrating dual ...
Ramtin Babaeipour, Matthew S. Fox, Grace Parraga, Alexei Ouriadov   +3 more
wiley   +1 more source

Characterization of Pulmonary Functional Abnormalities in Systemic Sclerosis Using Xenon MRI

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Xenon MRI is increasingly used to evaluate patients with interstitial lung disease (ILD) and pulmonary hypertension (PH), both of which are common manifestations of systemic sclerosis (SSc). As such, Xe‐MRI may be suited to interrogate lung function impairment in SSc.
Dawson Shaver, Steven Haworth, Evan Graumann, Bradie Frizzell, David H. Lee, Jiwoong Choi, Chase S. Hall, Scott M. Matson, Mark Hamblin, Mario Castro, Paul S. Schmidt, Peter J. Niedbalski   +11 more
wiley   +1 more source

MRI for Mixing Quality in Microfluidics

Magnetic Resonance in Chemistry, EarlyView.
Fluidic mixing in a micromixer: Paramagnetic relaxation enhancement and chemical shift differences were explored to reveal mixing quality at the small dimensions of an optically opaque y‐mixer. ABSTRACT Liquid state processes often involve mixing of process streams.
J. Götz, T. Rudszuck, L. Kontschak, T. Oerther, H. Nirschl, G. Guthausen   +5 more
wiley   +1 more source

Open-Source Multinuclear Low-Field Preclinical MRI Scanner. [PDF]

NMR Biomed
A step‐by‐step guideline for the construction of an open‐source multinuclear low‐field MRI scanner for preclinical studies is presented together with the first images acquired with the device. The scanner can detect 1H, 23Na, hyperpolarized 13C, and 15N signals at 66 mT. ABSTRACT Low‐field MRI (B0 ≤ 0.2 T) is emerging as a technology with the potential
Rodriguez GG, Korchak S, von Petersdorff-Campen C, Sucre O, Felger J, Mei R, Glöggler S.   +6 more
europepmc   +2 more sources

SAMBADENA Hyperpolarization of 13C‐Succinate in an MRI: Singlet‐Triplet Mixing Causes Polarization Loss

ChemistryOpen, 2019
The signal enhancement provided by the hyperpolarization of nuclear spins of biological molecules is a highly promising technique for diagnostic imaging.
Stephan Berner, Andreas B. Schmidt, Mirko Zimmermann, Dr. Andrey N. Pravdivtsev, Dr. Stefan Glöggler, Prof. Dr. Dr. h.c. Jürgen Hennig, PD Dr. Dominik von Elverfeldt, Prof. Dr. Jan‐Bernd Hövener   +7 more
doaj   +1 more source

Enabling Quantitative Benchtop 13C NMR Spectroscopy in Fast Continuous Flow

Magnetic Resonance in Chemistry, EarlyView.
Paramagnetic relaxation enhancement (PRE) accelerates polarization buildup in continuous‐flow benchtop 13$$ {}^{13} $$C NMR spectroscopy by the use of an immobilized PRE agent. By combining PRE with PENDANT polarization transfer, weak 13$$ {}^{13} $$C signals are enhanced even at high flow rates, enabling robust quantitative analysis of solvent ...
Sarah Mross, Hans Hasse, Kerstin Münnemann   +2 more
wiley   +1 more source

Quantitative Imaging of Pyruvate Metabolism in a Patient With Anaplastic Thyroid Cancer

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Magnetic resonance imaging using hyperpolarized (HP) [1‐13C]‐pyruvate enables assessment of pyruvate metabolism in vivo and offers new insight into metabolic changes in response to cancer therapy. Widely used semi‐quantitative metrics of pyruvate metabolism can be affected by physiological factors that are extrinsic to intracellular ...
James A. Bankson, Joshua S. Niedzielski, Collin J. Harlan, Yunyun Chen, Christopher M. Walker, Philip L. Lorenzi, Lin Tan, Vikas Kundra, Matthew E. Merritt, Mukundan Ragavan, Dawid Schellingerhout, Renjie He, Yao Ding, Sahana Datar, Qing Wang, Christine B. Peterson, Clifton D. Fuller, Vlad C. Sandulache, Stephen Y. Lai   +18 more
wiley   +1 more source