Results 131 to 140 of about 88,078 (299)

Repeatability of Metabolic Imaging With Hyperpolarized Pyruvate: Back‐to‐Back Neuroimaging and Blood Analysis

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose 13C MRI with hyperpolarized [1‐13C]pyruvate enables noninvasive imaging of metabolic pathways. Considering the high dose of pyruvate used in hyperpolarized 13C‐pyruvate studies, circulating 13C‐pyruvate and the resulting 13C‐lactate in plasma may influence subsequent pyruvate metabolism, yet the guidance on consecutive injections does ...
Jun Chen, Sung‐Han Lin, Jessica Sudderth, Kelley A. Derner, Crystal E. Harrison, Maheen Zaidi, Jeannie D. Baxter, Jeff Liticker, Zohreh Erfani, Craig R. Malloy, Marco C. Pinho, Ralph J. DeBerardinis, Jae Mo Park   +12 more
wiley   +1 more source

VQ‐Wave: A Physics‐Driven Spatiotemporal Deep Learning Approach for Noncontrast‐Enhanced Lung Ventilation and Perfusion MRI

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To develop a robust deep learning framework for noncontrast‐enhanced functional lung MRI, overcoming the limitations of spectral decomposition in the presence of physiological nonstationarity. Methods We introduce VQ‐Wave (Ventilation/Q‐perfusion Waveform‐based Assessment of Variable Evolutions), a physics‐driven spatiotemporal ...
Grzegorz Bauman, Pavlos Panos, Philipp Latzin, Oliver Bieri   +3 more
wiley   +1 more source

Glycolytic alterations as biomarkers in polycystic kidney disease: A study using a PKD1 knockout model in NRK‐52E rat kidney epithelial cells

Physiological Reports
Polycystic kidney disease (PKD) is a genetic disorder characterized by the formation of fluid‐filled cysts in the kidneys, often resulting in progressive renal impairment.
Ida Kjær Mieritz, Christoffer Laustsen, Esben Axelgaard, Sofie Rahbek Dorset, Rasmus O. Bak, Lotte Bonde Bertelsen   +5 more
doaj   +1 more source

Hemodynamic Modeling and Phase‐Adjustable Reconstruction of Hyperpolarized Cardiac 13C MRS Using 1H Cine and ECG Timing

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To deconvolve cardiac phase and hemodynamic effects in hyperpolarized (HP) [1‐13C]pyruvate and to develop a cardiac phase‐adjustable reconstruction framework. Methods Cardiac phase drift during dynamic acquisition of HP 13C MRS and its effect on dynamic signal fidelity were simulated using a digital cardiac phantom. A hemodynamic model
Sung‐Han Lin, Corey Mozingo, Crystal E. Harrison, Kelley A. Derner, Craig R. Malloy, Jae Mo Park   +5 more
wiley   +1 more source

Calcium activates SK channels in the intact human lens. [PDF]

, 2003
Collison, DJ, Duncan, G, Rhodes, JD
core   +1 more source

Ventilation Imaging of the Lung at 0.55T With Continuous Slice Cycling

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To propose and evaluate a novel method for pulmonary ventilation imaging, offering considerably improved SNR. Methods A continuous slice cycling (CSC) acquisition scheme is proposed to exclusively capture signal modulations from respiratory motion with increased SNR.
Andrea Leuthard, Grzegorz Bauman, Katrin E. Hostettler, Maurice Pradella, Oliver Bieri   +4 more
wiley   +1 more source

Flavonoids in Nasal Therapeutics: Biological Activities, Delivery Challenges, and Formulation Strategies–A Systematic Review

Phytotherapy Research, EarlyView.
Overview of the therapeutic potential of flavonoids in nasal delivery systems, highlighting their benefits to the human nasal cavity, and applications in the treatment of respiratory and brain‐related diseases. ABSTRACT Flavonoids represent a significant group of secondary metabolites.
Jeniffer Viviana Ramirez Hernández, Sara Elis Bianchi, Flávia Nathiely Silveira Fachel, Elizandra Braganhol, Sheila Porto de Matos, Valquíria Linck Bassani   +5 more
wiley   +1 more source

Preclinical Toxicity Screening of Sodium Dodecanoyloxybenzenesulfonate (LOBS) as a New Alternative Biocide Using In Vitro and In Vivo Models

Environmental Toxicology, EarlyView.
ABSTRACT Sodium hypochlorite is a well‐established biocide extensively used in both living and industrial environments; however, exposure to it or improper handling can harm the human body and the environment. Thus, safer alternatives to sodium hypochlorite are required.
Seung Eui Min, Seunghee Oh, Min Seong Jang, Kang‐Hyun Han   +3 more
wiley   +1 more source

US State Policy Contexts and Mental Health Among Working‐Age Adults

The Milbank Quarterly, EarlyView.
Policy Points States’ overarching policy contexts are a meaningful yet overlooked predictor of adults’ mental health, with more conservative contexts associated with worse mental health outcomes over a 30‐year period. Counterfactual analyses suggest that widespread policy shifts could meaningfully alter the national prevalence of mental distress ...
ILIYA GUTIN, JENNIFER KARAS MONTEZ, EMILY WIEMERS, SHANNON M. MONNAT, DOUGLAS A. WOLF   +4 more
wiley   +1 more source

US State Policy Index for Population Health Analyses

The Milbank Quarterly, EarlyView.
Policy Points Changes in states’ policy contexts since the 1980s may help explain why mortality rates among working‐age adults have risen and become more unequal across geographic areas. Investigating this pressing issue requires a new, industry‐standard measure of those contexts.
JENNIFER KARAS MONTEZ, ILIYA GUTIN, SHANNON M. MONNAT   +2 more
wiley   +1 more source