Results 141 to 150 of about 61,022 (308)
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose CGRP is a potent, clinically relevant coronary vasodilator known to play a role in cardioprotection. Here, we investigated the precise intracellular signalling pathways leading to vasodilation in small coronary arteries.
Lucy A. Donovan +4 more
wiley +1 more source
The third pathway: Endothelium-dependent hyperpolarization
, 1999 In response to various neurohumoral substances endothelial cells release nitric oxide (NO), prostacyclin and produce hyperpolarization of the underlying vascular smooth muscle cells, possibly by releasing another factor termed endothelium-derived ...
Félétou, M, Vanhoutte, PM
core
Third pathway: Endothelium-dependent hyperpolarization
, 2003 The mechanism of endothelium-dependent hyperpolarizations, once attributed to an elusive endothelium-derived hyperpolarizing factor (EDHF), is better understood.
Félétou, M +3 more
core +1 more source
Fn14 signalling participates in pristane‐induced murine lupus through exacerbating oxidative stress
British Journal of Pharmacology, EarlyView.Background and Purpose Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by oxidative stress and immune dysregulation. Fibroblast growth factor‐inducible 14 (Fn14) has been implicated in tissue injury, but its specific role in SLE pathogenesis remains unclear.
Zhu Yan +8 more
wiley +1 more source
Low-Cost Solution for Optical NMR Hyperpolarization
, 2019 Hyperpolarization can boost the low sensitivity of NMR spectroscopy and medical MRI, making it possible to record spectra of samples too dilute for standard NMR analyses.
Albrecht, Lucas
core
, 1997 Fujimura, N., E. Tanaka, S. Yamamoto, M. Shigemori, and H. Higashi. Contribution of ATP-sensitive potassium channels to hypoxic hyperpolarization in rat hippocampal CA1 neurons in vitro. J. Neurophysiol. 77: 378–385, 1997.
N. Fujimura +4 more
core +1 more source
Optimization of novel compounds using computer‐aided drug design for treatment of cardiac arrhythmia
British Journal of Pharmacology, EarlyView.Background and Purpose Loss‐of‐function mutations of the voltage‐gated Kv7.1 (KCNQ/KCNE1) channels lead to cardiac arrhythmia such as long QT syndrome, characterized by a prolonged QT interval . One strategy to correct the prolonged QT interval is to design molecules that activate KCNQ1/KCNE1 channels and restore the QT interval.
Jessica Jowais +4 more
wiley +1 more source
Hyperpolarized MRI theranostics in cancer
Frontiers in OncologyHyperpolarized magnetic resonance imaging (MRI) has emerged as a transformative tool in cancer diagnostics, enabling real-time, non-invasive assessment of tumor metabolism. By employing hyperpolarized molecular probes, such as [1- 13 C]pyruvate, energy metabolism and metabolic changes ...
Yamashita, Koya +3 more
openaire +2 more sources
The FEBS Journal, EarlyView.Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti +3 more
wiley +1 more source