Results 21 to 30 of about 61,022 (308)
Hyperpolarized NMR metabolomics
Current Opinion in Chemical Biology, 2023 Hyperpolarized NMR is a promising approach to address the sensitivity limits of conventional NMR metabolomics approaches, which currently fails to detect minute metabolite concentrations in biological samples. This review describes how tremendous signal enhancement offered by dissolution-dynamic nuclear polarization and parahydrogen-based techniques ...
Ribay, Victor +4 more
openaire +3 more sources
Hyperpolarized Views on the Roles of the Hyperpolarization-Activated Channels in Neuronal Excitability [PDF]
Epilepsy Currents, 2010 Upregulated H-Current in Hyperexcitable CA1 Dendrites after Febrile Seizures. Dyhrfjeld-Johnsen J, Morgan RJ, Csaba Foldy, Soltesz I., Front Cell Neurosci. 2008;2:2. doi:10.3389/neuro.03.002.2008. Somatic recordings from CA1 pyramidal cells indicated a persistent upregulation of the h-current ( I h
Noam, Yoav, Baram, Tallie Z
openaire +5 more sources
, 2023 Hyperpolarization chemistry based on reversible exchange of parahydrogen, also known as Signal Amplification By Reversible Exchange (SABRE), is a particularly simple approach to attain high levels of nuclear spin hyperpolarization, which can enhance NMR ...
Austin, Browning +9 more
core +1 more source
Spin Hyperpolarization in Modern Magnetic Resonance [PDF]
, 2023 Magnetic resonance techniques are successfully utilized in a broad range of scientific disciplines and in various practical applications, with medical magnetic resonance imaging being the most widely known example. Currently, both fundamental and applied
Budker, Dmitry +42 more
core +1 more source
Hyperpolarized MR Imaging: Neurologic Applications of Hyperpolarized Metabolism [PDF]
American Journal of Neuroradiology, 2009 Hyperpolarization is the general term for a method of enhancing the spin-polarization difference of populations of nuclei in a magnetic field. No less than 5 distinct techniques (dynamic nuclear polarization [DNP]; parahydrogen-induced polarization-parahydrogen and synthesis allow dramatically enhanced nuclear alignment [PHIP-PASADENA]; xenon/helium ...
B D, Ross +4 more
openaire +2 more sources
Frontiers in Cell and Developmental Biology, 2022 When mammalian spermatozoa are released in the female reproductive tract, they are incapable of fertilizing the oocyte. They need a prolonged exposure to the alkaline medium of the female genital tract before their flagellum gets hyperactivated and the ...
Bertrand de Prelle +2 more
doaj +1 more source
The cGMP-dependent protein kinase II Is an inhibitory modulator of the hyperpolarization-activated HCN2 channel [PDF]
, 2011 Opening of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels is facilitated by direct binding of cyclic nucleotides to a cyclic nucleotide-binding domain (CNBD) in the C-terminus. Here, we show for the first time that in the HCN2 channel
Biel Martin +14 more
core +1 more source
Detection of Pyridine Derivatives by SABRE Hyperpolarization at Zero Field
, 2022 Zero-field nuclear magnetic resonance (NMR) recently emerged as an interesting new analytical modality. While zero-field NMR provides new capabilities, it also suffers from some limitations associated, to a great degree, with low signal amplitude.
Oksana, Bondar +5 more
core +1 more source
Mapping of Absolute Host Concentration and Exchange Kinetics of Xenon Hyper-CEST MRI Agents
Pharmaceuticals, 2021 Xenon magnetic resonance imaging (MRI) provides excellent sensitivity through the combination of spin hyperpolarization and chemical exchange saturation transfer (CEST).
Martin Kunth +2 more
doaj +1 more source
Changes of intracellular sodium and potassium ion concentrations in frog spinal motoneurons induced by repetitive synaptic stimulation [PDF]
, 1982 A post-tetanic membrane hyperpolarization following repetitive neuronal activity is a commonly observed phenomenon in the isolated frog spinal cord as well as in neurons of other nervous tissues.
Ten Bruggencate, Gerrit +3 more
core +1 more source