Results 101 to 110 of about 2,671,885 (319)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Balancing Pipeline Parallelism with Vocabulary Parallelism
CoRRPipeline parallelism is widely used to scale the training of transformer-based large language models, various works have been done to improve its throughput and memory footprint. In this paper, we address a frequently overlooked issue: the vocabulary layers can cause imbalanced computation and memory usage across pipeline stages, worsening pipeline ...
Man Tsung Yeung +3 more
openaire +3 more sources
A Replacement Algorithm of Non-Maximum Suppression Base on Graph Clustering
ITM Web of Conferences, 2017 Non-maximum suppression is an important step in many object detection and object counting algorithms. In contrast with the extensive studies of object detection, NMS method has not caused too much attention.
Zhao Xin, Wang Yue-Qing, Dou Yong
doaj +1 more source
Strategic Responses to Parallel Trade [PDF]
This paper examines how pharmaceutical firms have responded to changes in intellectual property rights and trade barriers that legalized "parallel imports" within the European Union.
Margaret K. Kyle
core
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Parallel recognition of series-parallel graphs
Information and Computation, 1992 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +2 more sources
PRECONDITIONING OF VOXEL FEM ELLIPTIC SYSTEMS
TASK Quarterly, 2007 The presented comparative analysis concerns two iterative solvers for large-scale linear systems related to µFEM simulation of human bones. The considered scalar elliptic problems represent the strongly heterogeneous structure of real bone specimens ...
SVETOZAR MARGENOV, YAVOR VUTOV
doaj
DD-MIC(O) preconditioning of rotated trilinear FEM elasticity systems
Computer Assisted Methods in Engineering and Science, 2023 New results about preconditioning of rotated trilinear nonconforming FEM elasticity systems in the case of mesh anisotropy are presented. The solver of the arising linear system is based on the constructed efficient preconditioner of the coupled ...
I. Georgiev, S. Margenov
doaj
RIOT : a parallel input/output tracer [PDF]
, 2011 Input/output (I/O) operations can represent a significant proportion of the run-time when large scientific applications are run in parallel. Although there have been advances in the form of file-format libraries, file-system design and I/O hardware, a ...
Wright, Steven A. +3 more
core