Results 71 to 80 of about 3,910,298 (308)

A New Domain Decomposition Parallel Algorithm for Convection–Diffusion Problem

Mathematical Modelling and Analysis, 2014
Basing on overlapping domain decomposition, we construct a new parallel algorithm combined the method of subspace correction with least-squares procedure for solving time-dependent convection–diffusion problem. This algorithm is fully parallel.
Jiansong Zhang, Danping Yang
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Simultaneous Smoothing and Untangling of 2D Meshes Based on Explicit Element Geometric Transformation and Element Stitching

Applied Sciences, 2020
Mesh quality can affect both the accuracy and efficiency of numerical solutions. This paper first proposes a geometry-based smoothing and untangling method for 2D meshes based on explicit element geometric transformation and element stitching.
Shuli Sun, Zhihong Gou, Mingguang Geng
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

An efficient parallel algorithm for LISSOM neural network

, 2011
We present a parallel algorithm for laterally interconnected synergetically self-organizing map (LISSOM) neural network, a self-organizing map with lateral excitatory and inhibitory connections, to enhance the computational efficiency. A general strategy
張麗秋; Chang, Li-chiu;Chang, Fi-john
core   +1 more source

Parallel Homologous Search With Hirschberg Algorithm: A Hybrid MPI-Pthreads Solution. [PDF]

, 2007
In this paper, we apply two different parallel programming model, the message passing model using Message Passing Interface (MPI) and the multithreaded model using Pthreads, to-protein sequence homologous search.
Abdul Rashid, Nur'Aini, Abdullah, Rosni, Hj. Talib, Abdullah Zawawi   +2 more
core   +1 more source

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif, Diane Demailly, Gabriella A. Horvàth, Juan Dario Ortigoza Escobar, Nathalie Dorison, Mayté Castro Jiménez, Cécile A. Hubsch, Thomas Wirth, Gun‐Marie Hariz, Sophie Huby, Morgan Dornadic, Zohra Souei, Muhammad Mushhood Ur Rehman, Simone Hemm, Mehdi Boulaymen, Eduardo M. Moraud, Jocelyne Bloch, Xavier Vasques   +17 more
wiley   +1 more source

Enhancing Solar Convection Analysis With Multi‐Core Processors and GPUs

Engineering Reports
In the realm of astrophysical numerical calculations, the demand for enhanced computing power is imperative. The time‐consuming nature of calculations, particularly in the domain of solar convection, poses a significant challenge for Astrophysicists ...
Arash Heidari, Zahra Amiri, Mohammad Ali Jabraeil Jamali, Nima Jafari Navimipour   +3 more
doaj   +1 more source