Results 141 to 150 of about 1,515,905 (267)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Air Pollutants and Breast Cancer Risk: A Parallel Analysis of Five Large US Prospective Cohorts. [PDF]

Am J Public Health
White AJ, Hart JE, Quraishi SM, Bookwalter DB, Sweeney MR, Spalt EW, Hendryx MS, Irvin VL, Lane DS, Shadyab AH, Sealy-Jefferson S, Neuhouser ML, Whitsel EA, Kaufman JD, Laden F, Sandler DP.   +15 more
europepmc   +1 more source

Response: Commentary: Predictors of Colorectal Cancer Screening in Two Underserved U.S. Populations: A Parallel Analysis. [PDF]

Front Oncol, 2020
Reisinger SA, Bernardo BM, Gross AL, Young G, Baltic R, Blot WJ, Paskett ED.   +6 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Simultaneous isolation and parallel analysis of genomic DNA and total RNA: A comprehensive approach. [PDF]

Mol Ther Methods Clin Dev
Rouse J, Wei H, Annas A, Scott D, Bhagchandani D, Beard C.   +5 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Massively parallel analysis of genotype-dependent enhancer activity among atopic dermatitis genetic risk variants. [PDF]

J Allergy Clin Immunol
Shook MS, Lu X, Chen X, Edsall LE, Granitto M, Virolainen SJ, Forney C, Donmez OA, Parameswaran S, Fadden C, Dexheimer PJ, Jenkins S, Grashel B, Kaufman KM, Hershey GK, Martin LJ, Satish L, Weirauch MT, Kottyan LC.   +18 more
europepmc   +1 more source

Commentary: Predictors of Colorectal Cancer Screening in Two Underserved U.S. Populations: A Parallel Analysis. [PDF]

Front Oncol, 2020
Johnson R, Bail JR, Behring M, Orlandella R, Williams V, Halilova KI, Hoenemeyer TW.   +6 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Insights into respiratory illness at the population level through parallel analysis of pharmaceutical and viral markers in wastewater. [PDF]

Nat Water
Baumgartner S, Salvisberg M, Schmidhalter P, Julian TR, Ort C, Singer H.   +5 more
europepmc   +1 more source