Results 141 to 150 of about 1,526,420 (267)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Air Pollutants and Breast Cancer Risk: A Parallel Analysis of Five Large US Prospective Cohorts. [PDF]

Am J Public Health
White AJ, Hart JE, Quraishi SM, Bookwalter DB, Sweeney MR, Spalt EW, Hendryx MS, Irvin VL, Lane DS, Shadyab AH, Sealy-Jefferson S, Neuhouser ML, Whitsel EA, Kaufman JD, Laden F, Sandler DP.   +15 more
europepmc   +1 more source

Response: Commentary: Predictors of Colorectal Cancer Screening in Two Underserved U.S. Populations: A Parallel Analysis. [PDF]

Front Oncol, 2020
Reisinger SA, Bernardo BM, Gross AL, Young G, Baltic R, Blot WJ, Paskett ED.   +6 more
europepmc   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Simultaneous isolation and parallel analysis of genomic DNA and total RNA: A comprehensive approach. [PDF]

Mol Ther Methods Clin Dev
Rouse J, Wei H, Annas A, Scott D, Bhagchandani D, Beard C.   +5 more
europepmc   +1 more source

Commentary: Predictors of Colorectal Cancer Screening in Two Underserved U.S. Populations: A Parallel Analysis. [PDF]

Front Oncol, 2020
Johnson R, Bail JR, Behring M, Orlandella R, Williams V, Halilova KI, Hoenemeyer TW.   +6 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Massively parallel analysis of genotype-dependent enhancer activity among atopic dermatitis genetic risk variants. [PDF]

J Allergy Clin Immunol
Shook MS, Lu X, Chen X, Edsall LE, Granitto M, Virolainen SJ, Forney C, Donmez OA, Parameswaran S, Fadden C, Dexheimer PJ, Jenkins S, Grashel B, Kaufman KM, Hershey GK, Martin LJ, Satish L, Weirauch MT, Kottyan LC.   +18 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source