Results 121 to 130 of about 52,467,368 (351)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Parallel Composition and Bulk Synchronous Parallel Functional Programming

, 2001
The work described here is part of our research program to investigate new paradigms for declarative parallel programming through special interpretations of standard semantics. Our approach is a purely functional approach to programming of BSP algorithms
Parallel Composition And, Frederic Loulergue   +1 more
core  

Enabling Detailed, Biophysics-Based Skeletal Muscle Models on HPC Systems

Frontiers in Physiology, 2018
Realistic simulations of detailed, biophysics-based, multi-scale models often require very high resolution and, thus, large-scale compute facilities.
Chris P. Bradley, Nehzat Emamy, Nehzat Emamy, Thomas Ertl, Thomas Ertl, Dominik Göddeke, Dominik Göddeke, Andreas Hessenthaler, Andreas Hessenthaler, Thomas Klotz, Thomas Klotz, Aaron Krämer, Aaron Krämer, Michael Krone, Michael Krone, Benjamin Maier, Benjamin Maier, Miriam Mehl, Miriam Mehl, Tobias Rau, Tobias Rau, Oliver Röhrle, Oliver Röhrle   +22 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Psychometric evaluation and factor structure of the Persian coping strategies questionnaire in chronic low back pain patients

Journal of Current Oncology and Medical Sciences
Introduction: This study aimed to investigate the factor structure and psychometric properties of the Coping Strategies Questionnaire (CSQ) in Persian in people with non-specific chronic low back pain (NSCLBP).
Sarvenaz Karimi-GhasemAbad, Behnam Akhbari, Mahyar Salavati, Saeed Talebian Moghaddam, Ahmad Saeedi, Mahsa Seydi, Mohammad Ali Shakoorianfard   +6 more
doaj  

Notes on Number Theory

Mathematics
This paper presents a set of survey-style notes linking core themes of pure algebra with central topics in algebraic and analytic number theory. We begin with finite extensions of Q and describe algebraic number fields through their realization as finite-
Miroslav Stoenchev, Slavi Georgiev, Venelin Todorov   +2 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

PACE: A Toolset to Investigate and Predict Performance in Parallel Systems [PDF]

, 1996
A toolset, PACE (PerforAnCE analysis environment) for predicting and analysing performance issues in parallel systems is presented here. In this toolset expert knowledge about performance evaluation techniques is not required as a prerequisite for its ...
D. J. Kerbyson, Nudd, G. R., Harper, J. S., Craig, A. (Adam), Kerbyson, D. J., A. Craig, G. R. Nudd, J. Harper   +7 more
core  

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Parallel R&D Paths Revisited [PDF]

This paper revisits the logic of pursuing parallel R&D paths when there is uncertainty as to which approaches will succeed technically and/or economically. Previous findings by Richard Nelson and the present author are reviewed.
Scherer, F. M.
core