Results 101 to 110 of about 4,743,611 (293)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
MathematicsThis paper presents a set of survey-style notes linking core themes of pure algebra with central topics in algebraic and analytic number theory. We begin with finite extensions of Q and describe algebraic number fields through their realization as finite-
Miroslav Stoenchev +2 more
doaj +1 more source
21st Century Simulation: Exploiting High Performance Computing and Data Analysis [PDF]
, 2004 This paper identifies, defines, and analyzes the limitations imposed on Modeling and Simulation by outmoded paradigms in computer utilization and data analysis.
Baer, Garth D. +2 more
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Enabling Detailed, Biophysics-Based Skeletal Muscle Models on HPC Systems
Frontiers in Physiology, 2018 Realistic simulations of detailed, biophysics-based, multi-scale models often require very high resolution and, thus, large-scale compute facilities.
Chris P. Bradley +22 more
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
A Survey of Galaxy Pairs in the SDSS Photometric Images based on Faster-RCNN
The Astronomical JournalGalaxy pairs hold significant importance in understanding the evolution of galaxies, and the extensive search for a large sample of galaxy pairs is meaningful.
Chen-hui Shi +7 more
doaj +1 more source
Extraction Protocol for Parallel Analysis of Proteins and DNA from Ancient Teeth and Dental Calculus. [PDF]
J Proteome Res, 2023 Chocholova E +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source