Results 81 to 90 of about 4,743,611 (293)

Integrating Parallelization Strategies for Linkage Analysis [PDF]

Computers and Biomedical Research, 1995
We describe a second parallel implementation of the ILINK program from the LINKAGE package that improves on our previous implementation. To improve running time we integrated the strategy of parallel estimation of the gradient at a candidate recombination fraction vector with a previously implemented strategy for evaluating in parallel the likelihood ...
S K, Gupta, A A, Schäffer, A L, Cox, S, Dwarkadas, W, Zwaenepoel   +4 more
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A Comparison of Methods for Determining the Number of Factors to Retain in Exploratory Factor Analysis for Categorical Indicator Variables

Psychology International
Exploratory factor analysis (EFA) is a widely used tool in the social sciences. Researchers employ it to identify the latent structure underlying observed indicator variables during the process of scale development, theory construction, and comparison of
Holmes Finch
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Kinematic Analysis Of Tricept Parallel Manipulator

International Islamic University Malaysia Engineering Journal, 2012
Parallel manipulators consist of fixed and moving platforms connected to each other with some actuated links. They have some significant advantages over their serial counterparts.
Mir Amin Hosseini, Hamid-Reza Mohammadi Daniali   +1 more
doaj   +1 more source

Analysis of Parallel Graph Applications

2024 IEEE 30th International Conference on Parallel and Distributed Systems (ICPADS)
Despite the increasing computing power of shared memory systems with high core counts, parallel graph processing frameworks cannot exploit it effectively. The reason behind this is the inherent challenges in parallel graph algorithms, which are efficient management of dynamically created tasks and irregular data access patterns.
Atik, Funda, Yesil, Serif, Ouarnoughi, Hamza, Niar, Smail, Öztürk, Özcan   +4 more
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Parallel coupled ring resonators performance analysis

Results in Physics, 2019
We have investigated the system performance of several parallel coupled ring resonators. An optical network analyzer is utilized to analyze the output spectrums (frequency response) from the throughput and drop ports of the proposed system while it is ...
Satish Addanki, I.S. Amiri, P. Yupapin
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source