Results 61 to 70 of about 1,507,629 (267)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Parallel coupled ring resonators performance analysis

open access: yesResults in Physics, 2019
We have investigated the system performance of several parallel coupled ring resonators. An optical network analyzer is utilized to analyze the output spectrums (frequency response) from the throughput and drop ports of the proposed system while it is ...
Satish Addanki, I.S. Amiri, P. Yupapin
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Parallel architectures for image analysis [PDF]

open access: yes
This thesis is concerned with the problem of designing an architecture specifically for the application of image analysis and object recognition. Image analysis is a complex subject area that remains only partially defined and only partially solved. This makes the task of designing an architecture aimed at efficiently implementing image analysis and ...
openaire   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Partitioning Dichotomous Items Using Mokken Scale Analysis, Exploratory Graph Analysis and Parallel Analysis: A Monte Carlo Simulation

open access: yesMethodology
Estimating the number of latent factors underlying a set of dichotomous items is a major challenge in social and behavioral research. Mokken scale analysis (MSA) and exploratory graph analysis (EGA) are approaches for partitioning measures consisting of ...
Gomaa Said Mohamed Abdelhamid   +3 more
doaj   +1 more source

Kinematic Analysis of 3-SPS/UPR Parallel Worktable

open access: yesJixie chuandong, 2022
A worktable of 3-SPS/UPR parallel mechanism is proposed, which is used to assist the less degree of freedom machine tool to process the surface of the workpiece. The kinematic screw matrix of the 3-SPS/UPR parallel mechanism is established; its degree of
Bai Xueqing, Wang Yuan, Li You
doaj  

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

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