Results 51 to 60 of about 1,507,629 (267)
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
The Patient Health Questionnaire-9 (PHQ-9) is an effective tool for identifying depressive disorders in diverse populations, making it a valuable resource in both clinical practice and research.
Tyrone B. Pretorius +1 more
doaj +1 more source
Positioning Accuracy Analysis of the Parallel Mechanism Near Singular Positions
This paper presents a method of numerical modelling of parallel mechanisms with clearances in their kinematic pairs taken into account. The pairs with clearances are modelled as shape connections based on constraints in the form of contact interactions ...
J. Bałchanowski
doaj +1 more source
Parallel Factorizations in Numerical Analysis
15 pages, 5 ...
Pierluigi Amodio, BRUGNANO, LUIGI
openaire +4 more sources
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Exploratory factor analysis (EFA) is a widely used tool in the social sciences. Researchers employ it to identify the latent structure underlying observed indicator variables during the process of scale development, theory construction, and comparison of
Holmes Finch
doaj +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Kinematic Analysis Of Tricept Parallel Manipulator
Parallel manipulators consist of fixed and moving platforms connected to each other with some actuated links. They have some significant advantages over their serial counterparts.
Mir Amin Hosseini +1 more
doaj +1 more source
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source

