Results 91 to 100 of about 841,230 (289)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
A preliminary evaluation of high-performance advanced regional eta-coordinate model (H-AREM)
Atmospheric and Oceanic Science Letters, 2017 This paper preliminarily evaluates the speedup, scalability, and prediction skill of the high-performance advanced regional eta coordinate model (H-AREM), which is based on several parallel processing methods and decomposition strategies.
Yu-Feng CHENG +3 more
doaj +1 more source
Parallel algorithms and architecture for computation of manipulator forward dynamics [PDF]
Parallel computation of manipulator forward dynamics is investigated. Considering three classes of algorithms for the solution of the problem, that is, the O(n), the O(n exp 2), and the O(n exp 3) algorithms, parallelism in the problem is analyzed. It is
Bejczy, Antal K., Fijany, Amir
core +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Applied Sciences, 2018 The goal of this study involves developing an efficient and accurate parallel computation method for two-phase flow problems including complex moving foreign bodies.
Minho Ha +5 more
doaj +1 more source
, 2023 AbstractThe concept of parallelism of computations is very important to obtain the results required by the algorithms of big data processing applied in several domains, like ML, AI, neural networks, approximate computing, etc. In this chapter the use of and stations and of their respective generation/synchronization policies are described [12]. Three
openaire +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard +12 more
wiley +1 more source
Optimistic barrier synchronization [PDF]
Barrier synchronization is fundamental operation in parallel computation. In many contexts, at the point a processor enters a barrier it knows that it has already processed all the work required of it prior to synchronization.
Nicol, David M.
core +1 more source