Results 141 to 150 of about 127,054 (312)
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
PRAM implementation on fine-grained MIMD multicomputers [PDF]
The more user-friendly tools for expressing data-parallelism are encompassed by the PRAM language mechanisms (mainly, global addressing space, implicit processes synchronization).
Baude, Francoise
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Scalability by parallel computation in RMut.
, 2019 We compared the running times for calculating average sensitivity of the HSN in three modes: serial computation, parallel computation on multi-core CPU (denoted as “parallel CPU”), and parallel computation on GPU (denoted as “parallel GPU”). The knockout
Yung-Keun Kwon (79262) +1 more
core +1 more source
Sensitivity analysis of agent-based simulation utilizing massively parallel computation and interactive data visualization. [PDF]
PLoS One, 2019 Niida A, Hasegawa T, Miyano S.
europepmc +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
A High-Order Fractional Parallel Scheme for Efficient Eigenvalue Computation
Fractal and FractionalEigenvalue problems play a fundamental role in many scientific and engineering disciplines, including structural mechanics, quantum physics, and control theory.
Mudassir Shams, Bruno Carpentieri
doaj +1 more source
Parallel Computation of EM Backscattering from Large Three-Dimensional Sea Surface with CUDA. [PDF]
Sensors (Basel), 2018 Linghu L, Wu J, Wu Z, Wang X.
europepmc +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source