Results 151 to 160 of about 127,054 (312)

A Parallel semantics for normal logic programs plus time

, 2013
It is proposed that Normal Logic Programs with an explicit time ordering are a suitable basis for a general purpose parallel programming language. Examples show that such a language can accept real-time external inputs and outputs, and mimic assignment ...
Cleary, John G., Clayton, Roger, Utting, Mark   +2 more
core  

Giga protocol for unlocking trustless parallel computation in blockchains

Discover Computing
In this paper, we introduce GIGA, a SNARK-based protocol that enables trustless parallel execution of transactions, processing non-conflicting operations concurrently, while preserving security guarantees and state consistency.
Alberto Garoffolo, Dmytro Kaidalov, Roman Oliynykov, Daniele Di Tullio, Mariia Rodinko   +4 more
doaj   +1 more source

Parallel computation with molecular-motor-propelled agents in nanofabricated networks. [PDF]

Proc Natl Acad Sci U S A, 2016
Nicolau DV, Lard M, Korten T, van Delft FC, Persson M, Bengtsson E, Månsson A, Diez S, Linke H, Nicolau DV.   +9 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Adapting the interior point method for the solution of LPs on serial, coarse grain parallel and massively parallel computers

, 1990
In this paper we describe a unified scheme for implementing an interior point algorithm (IPM) over a range of computer architectures. In the inner iteration of the IPM a search direction is computed using Newton's method.
Levkovitz, R, Mitra, G, J Andersen, M Tamiz, Tamiz, M, Andersen, J, G Mitra, R Levkovitz   +7 more
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Making State Explicit for Imperative Big Data Processing [PDF]

, 2014
Data scientists often implement machine learning algorithms in imperative languages such as Java, Matlab and R. Yet such implementations fail to achieve the performance and scalability of specialised data-parallel processing frameworks.
Kalyvianaki, Evangelia, Migliavacca, M., Migliavacca, M, Castro Fernandez, Raul, Fernandez, R. C., Fernandez, RC, Migliavacca, Matteo, Pietzuch, P., Kalyvianaki, E, Pietzuch, Peter, Pietzuch, PR, Kalyvianaki, E.   +11 more
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source