Results 111 to 120 of about 329,729 (302)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Parallel loss-of-function at the RPM1 bacterialresistance locus in Arabidopsis thaliana

Frontiers in Plant Science, 2012
Dimorphism at the RPM1 locus is well documented in natural populations of Arabidopsis thaliana and has been portrayed as a long-term balanced polymorphism.
Laura Ellen Rose, Susanna eAtwell, Murray eGrant, Eric B Holub   +3 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

An Evolution of Parallel Pipeline System with the Classification of Operation Code

, 2018
Objectives: Multiple pipelines are used to enhance the throughput. Multiple data are fetched at pipeline and classified into different data by selecting and decoding appropriate bits in Instruction field.
Mr Abdisa L, Adinew Belay, Dr. Narasimha Rao Yamarthi   +2 more
core  

Comparative transcriptomics reveals the conserved building blocks involved in parallel evolution of diverse phenotypic traits in ants [PDF]

, 2016
Background Reproductive division of labor in eusocial insects is a striking example of a shared genetic background giving rise to alternative phenotypes, namely queen and worker castes.
Schiøtt, Morten, Mikheyev, Alexander, Claire Morandin, Tin, Mandy M. Y., Jes Søe Pedersen, Mikheyev, Alexander S, Kazuki Tsuji, Luigi Pontieri, Schiott, Morten, Gómez López, Crisanto, Pedersen, Jes Søe, Crisanto Gómez, Tin, Mandy M Y, Pontieri, Luigi, Mikheyev, Alexander S., Helanterä, Heikki, Gómez, Crisanto, Morandin, Claire, Tsuji, Kazuki, Pedersen, Jes S, Tin, Mandy M.Y., Abril, Sílvia, Heikki Helanterä, Mandy M. Y. Tin, Sundström, Liselotte, Pedersen, Jes Soe, Liselotte Sundström, Alexander S. Mikheyev, Sílvia Abril, Morten Schiøtt   +29 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Parallel evolution of leaf morphology in gnetophytes

, 2015
In the present paper, an ephedroid macrofossil species from the Early Cretaceous Yixian Formation of western Liaoning of China is described as new to science: Ephedra multinervia Yang et Lin, sp. nov.
Ferguson, David K., Lin, Longbiao, Yang, Yong   +2 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Parallel evolution of nacre building gene sets in molluscs

, 2010
The capacity to biomineralize is closely linked to the rapid expansion of animal life during the early Cambrian, with many skeletonized phyla first appearing in the fossil record at this time.
Degnan, Bernard M, Piquemal, D., Piquemal, David, Kube, M., McDougall, Carmel, Piquernal, David, Moase, P., Moase, Patrick, Reinhardt, Richard, Jackson, Daniel J., Woodcroft, B., Woodcroft, Ben, Degnan, B., Rose, Robert A, Rokhsar, Daniel S., Jackson, Daniel J, Rose, R., Reinhardt, R., Jackson, Daniel John, Jackson, D., McDougall, C., Rose, Robert A., Rokhsar, Daniel S, Rokhsar, D., Kube, Michael, Joubert, C., Degnan, Bernard M., Montagnani, Caroline, Woodcroft, Ben J., Montagnani, C., Joubert, Caroline   +30 more
core   +1 more source