Results 101 to 110 of about 329,729 (302)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Delimited Massively Parallel Algorithm based on Rules Elimination for Application of Active Rules in Transition P Systems

, 2007
In the field of Transition P systems implementation, it has been determined that it is very important to determine in advance how long takes evolution rules application in membranes.
Gil Rubio, Fco. Javier, Fernández Muñoz, Luis, Tejedor Cerbel, Jorge A., Arroyo Montoro, Fernando   +3 more
core  

Crop plants as models for understanding plant adaptation and diversification

Frontiers in Plant Science, 2013
Since the time of Darwin, biologists have understood the promise of crop plants and their wild relatives for providing insight into the mechanisms of phenotypic evolution.
Kenneth M Olsen, Jonathan F Wendel
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Parallel combinator reduction : some performance bounds [PDF]

A parallel graph reduction machine simulator is described. This performs combinator reduction and can simulate various different parallel reduction strategies. A number of functional programs are examined, and experimental results presented comparing the
Joy, Mike, Axford, Tom
core  

A century of intermittent eco‐evolutionary feedbacks resulted in novel trait combinations in invasive Great Lakes alewives (Alosa pseudoharengus)

Evolutionary Applications, 2020
Species introductions provide opportunities to quantify rates and patterns of evolutionary change in response to novel environments. Alewives (Alosa pseudoharengus) are native to the East Coast of North America where they ascend coastal rivers to spawn ...
Shelby E. Smith, Eric P. Palkovacs, Brian C. Weidel, David B. Bunnell, Andrew W. Jones, Devin D. Bloom   +5 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Pleiotropy increases parallel selection signatures during adaptation from standing genetic variation

eLife
The phenomenon of parallel evolution, whereby similar genomic and phenotypic changes occur across replicated pairs of populations or species, is widely studied.
Wei-Yun Lai, Sheng-Kai Hsu, Andreas Futschik, Christian Schlötterer   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Parallel genetic evolution and speciation from standing variation

Evolution Letters, 2019
Adaptation often proceeds from standing variation, and natural selection acting on pairs of populations is a quantitative continuum ranging from parallel to divergent. Yet, it is unclear how the extent of parallel genetic evolution during adaptation from
Ken A. Thompson, Matthew M. Osmond, Dolph Schluter   +2 more
doaj   +1 more source