Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Exploratory factor analysis (EFA) is a widely used tool in the social sciences. Researchers employ it to identify the latent structure underlying observed indicator variables during the process of scale development, theory construction, and comparison of
Holmes Finch
doaj +1 more source
Dual-Symmetric Parallel Factor Analysis Using Procrustes Estimation And Khatri-Rao Factorization
Publication in the conference proceedings of EUSIPCO, Bucharest, Romania ...
Haardt, M. +3 more
openaire +1 more source
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Fluorescence regional integration combined with parallel factor analysis to quantify fluorescencent spectra for dissolved organic matter released from manure biochars. [PDF]
Peng N, Wang K, Tu N, Liu Y, Li Z.
europepmc +1 more source
Throughput Optimal On-Line Algorithms for Advanced Resource Reservation in Ultra High-Speed Networks
Advanced channel reservation is emerging as an important feature of ultra high-speed networks requiring the transfer of large files. Applications include scientific data transfers and database backup. In this paper, we present two new, on-line algorithms
Cohen, Reuven +2 more
core +2 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Assessing the chemical compositions and disinfection byproduct formation of biofilms: Application of fluorescence excitation-emission spectroscopy coupled with parallel factor analysis. [PDF]
Li L +4 more
europepmc +1 more source
Performance analysis of parallel supernodal sparse LU factorization
We investigate performance characteristics for the LU factorization of large matrices with various sparsity patterns. We consider supernodal right-looking parallel factorization on a bi-dimensional grid of processors, making use of static pivoting. We develop a performance model and we validate it using the implementation in SuperLU_DIST, the real ...
Grigori, Laura, Li, Xiaoye S.
openaire +1 more source
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source

