Results 121 to 130 of about 1,337,477 (299)

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

Advanced Science, EarlyView.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang   +10 more
wiley   +1 more source

The Strategic Effects of Parallel Trade～Market stealing and wage cutting～ [PDF]

Why do producers often accept parallel trade in some markets such as automobiles, clothing, toys and consumer electronics? This paper identifies two new factors, viz., market stealing and union-wage cutting, which may make parallel trading beneficial to ...
Arijit Mukherjee, Laixun Zhao
core  

Integrative Omics Analysis Reveals the Regulation of Hypoxia Tolerance in Large Yellow Croaker (Larimichthys crocea) via the Lipoic Acid Synthase (lias) Gene

Advanced Science, EarlyView.
Lipoic acid synthase (lias) can regulate α‐KG levels through lipoylation, thereby negatively regulating HIF‐1α protein levels via PHD under hypoixa. The Hap2 allele of lias exhibits lower expression levels than Hap1, leading to the accumulation of more HIF‐1α protein and thereby enhancing hypoxia tolerance. ABSTRACT Hypoxia stress seriously affects the
Jie Ding, Songpeng Jia, Ran Meng, Xuelei Wang, Xiongfei Wu, Weiliang Shen, Yibo Zhang, Junquan Zhu   +7 more
wiley   +1 more source

The E3 Ubiquitin Ligase RLIM Safeguards Oligodendrocyte Development and Myelination by Targeting SLC7A11 for Polyubiquitination to Regulate Ferroptotic Resistance

Advanced Science, EarlyView.
RLIM‐mediated SLC7A11 polyubiquitination is required for SPTBN2‐mediated trafficking and membrane localization of SLC7A11, which enables oligodendrocyte precursor cells to be resistant to ferroptosis and safeguards oligodendrocyte lineage progression and thus myelination.
Yuwei Li, Haijun Zhang, Jieya Zhou, Shiyu Yang, Jingmei Cha, Gaofeng Yan, Shuhua Zhao, Bingyu Mao, Pengcheng Ma   +8 more
wiley   +1 more source

Parallel computational fluid dynamics : implementations and results using parallel computers : proceedings of the Parallel CFD '95 Conference, Pasadena, CA, U.S.A., 26-29 June, 1995 /

, 1996
Parallel Computational Fluid Dynamics(CFD) is an internationally recognised fast-growing field. Since 1989, the number of participants attending Parallel CFD Conferences has doubled. In order to keep track of current global developments, the Parallel CFD
Parallel CFD Conference(1995 :Pasadena, Calif.), Ecer, Akin.   +1 more
core  

Impact of the World Trade Organization TRIPS Agreement on the pharmaceutical industry in Thailand

Bulletin of the World Health Organization, 2001
The 1994 World Trade Organization (WTO) Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS) established minimum universal standards in all areas of intellectual property. It is intended to implement these standards globally through
Supakankunti Siripen, Janjaroen Wattana S., Tangphao Oranee, Ratanawijitrasin Sauwakon, Kraipornsak Paitoon, Pradithavanij Pirus   +5 more
doaj  

Transformation of a Vase Canopy into a Planar Parallel U-System in an Almond Orchard: Preliminary Results

Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Horticulture
The almond is a species that it is highly appreciated due to its nutritional properties, showing interest to fruit growers. This makes it necessary to adopt modern culture technologies for the species.
Mihaela BĂLUȚĂ, Florin STĂNICĂ
doaj   +1 more source

PERFORMANCE PARAMETERS OF PARALLEL IMPORT

Vestnik Volgogradskogo gosudarstvennogo universiteta. Ekonomika
Parallel imports are a necessary measure of state economic policy under unprecedented sanctions pressure, exerting both positive and negative effects on the economy. Administrative and quantitative performance indicators for parallel imports are defined. Adherence to these indicators minimizes (prevents) their negative impact on the economy and ensures
Alla Litvinova, Elena Loginova, Maria Parfenova   +2 more
openaire   +1 more source

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

Advanced Science, EarlyView.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo, Hansen Lin, Haoqian Feng, Lei Tan, Xi Liu, Yong Huang, Junjie Cen, Jiajie Chen, Xinwei Zhou, Mingjie Lin, Wuyuan Liao, Zheyu Ai, Minyu Chen, Yinghan Wang, Wei Chen, Junhang Luo, Yanping Liang   +16 more
wiley   +1 more source

Fatty Acid Binding Protein 5 Mediates Astrocytic Pyroptosis and Neuroinflammation in Epilepsy via cGAS/STING Pathway

Advanced Science, EarlyView.
Astrocytic FABP5 promotes mitochondrial stress, cGAS‐STING pathway activation, pyroptosis, and neuroinflammation in epilepsy, contributing to seizure pathology. Genetic targeting of FABP5 or pharmacological inhibition of STING alleviates epileptic phenotypes, highlighting a potential therapeutic strategy for epilepsy.
Chen Chen, Yao Zhao, Yangye Lian, Yifei Hou, Lifen Gong, Tingting Wu, Yulin Yang, Jiaqi Zhu, Xin Wang, Kaihua Zhang, Jing Ding   +10 more
wiley   +1 more source