Results 111 to 120 of about 2,520,496 (344)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Analysis of the Design Space and Dexterity of a Planar Two Degree of Freedom Parallel Manipulator

Jixie chuandong, 2015
A novel planar two degree of freedom parallel manipulator is presented,its moving platform of the manipulator has smaller inertia and the output of the manipulator is planar translational motion.Unlike the traditional optimum analysis method,not only the
Wang Bing, Nie Xumeng, Han Shukui
doaj  

Pose Planning for the Feed Support System of FAST

Advances in Mechanical Engineering, 2014
A six-cable driven parallel manipulator and an A-B rotator in the feed support system of the Five-hundred-meter Aperture Spherical radio Telescope (FAST) are adopted for realizing the position and pose of nine feeds.
Rui Yao, Wenbai Zhu, Caihong Sun, Hui Li, Jinghai Sun   +4 more
doaj   +1 more source

Electromagnetic attachment mechanism [PDF]

, 1992
An electromagnetic attachment mechanism is disclosed for use as an end effector of a remote manipulator system. A pair of electromagnets, each with a U-shaped magnetic core with a pull-in coil and two holding coils, are mounted by a spring suspension ...
Monford, Leo G., Jr.
core   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Cartesian Stiffness Matrix Mapping of a Translational Parallel Mechanism with Elastic Joints

International Journal of Advanced Robotic Systems, 2012
This paper is devoted to calculating the Cartesian stiffness matrix of a translational parallel manipulator with elastic joints. The calculation takes into account the contribution of the Jacobian variation because of the change of manipulator ...
Maurizio Ruggiu
doaj   +1 more source

Design of a wrist and operator interface for an agricultural manipulator : a thesis presented in partial fulfilment of the requirements for the degree of Master of Technology in Engineering and Automation at Massey University [PDF]

, 2000
Roadside mowing and tree pruning has always been a job that most people would consider as unpleasant. This project is concerned with the development of a system to make these tasks simpler, safer and more pleasant for the operator.
Noaro, Adrian Peter Charles
core  

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source

Force/Position Hybrid Control of 6PUS-UPU Redundant Driven Parallel Manipulator Based on 2-DOF Internal Model Control

Journal of Control Science and Engineering, 2014
To improve control performance of parallel manipulator, servo control is optimized according to 2-DOF control with Internal Model Control. Position loop of the controller is redesigned based on the original current loop and speed loop.
Kuijing Zheng, Chao Wang
doaj   +1 more source