Results 101 to 110 of about 13,001,808 (334)

Parallel mechanisms with adjustable link parameters

Proceedings. 2000 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS 2000) (Cat. No.00CH37113), 2002
There has been always a workspace problem with parallel mechanisms. This paper discusses the workspace of the parallel mechanisms and its enlargement by adjusting their link parameters. The basic idea is to cover a whole required range of workspace with small pieces of one.
Tatsuo Arai, Yoshihiko Koseki, Kazunari Takayama, Kenji Inoue, Yasushi Mae   +4 more
openaire   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Geometric Modeling and Error Propagation Analysis of an Over-Constrained Spindle Head with Kinematic Interactions

Machines
This study presents a comprehensive geometric modeling and error propagation analysis for a 3-degrees-of-freedom spindle head, focusing on an over-constrained parallel mechanism.
Yifeng Shen, Tengfei Tang, Hanliang Fang
doaj   +1 more source

Synthesis of Planar Parallel Mechanism [PDF]

, 2012
Parallel mechanisms are found as positioning platforms in several applications in robotics and production engineering. Today there are various types of these mechanisms based on the strcture, type of joints and degree of freedom.
Nigam, Kushagra
core  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Kinematically Redundant Octahedral Motion Platform for Virtual Reality Simulations

, 2017
We propose a novel design of a parallel manipulator of Stewart Gough type for virtual reality application of single individuals; i.e. an omni-directional treadmill is mounted on the motion platform in order to improve VR immersion by giving feedback to ...
B Dasgupta, DM Downing, FM Hamdoon, J Kotlarski, J Lee, J Wang, J-P Merlet, J-P Merlet, KH Hunt, LT Schreiber, P Bande, Y Cao   +11 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Expander $\ell_0$-Decoding [PDF]

, 2015
We introduce two new algorithms, Serial-$\ell_0$ and Parallel-$\ell_0$ for solving a large underdetermined linear system of equations $y = Ax \in \mathbb{R}^m$ when it is known that $x \in \mathbb{R}^n$ has at most $k < m$ nonzero entries and that $A$ is
Mendoza-Smith, Rodrigo, Tanner, Jared
core   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source