Results 101 to 110 of about 2,384,762 (293)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Research on High Precision Stiffness Modeling Method of Redundant Over-Constrained Parallel Mechanism. [PDF]

Sensors (Basel), 2023
Wang S, Li H, Han X, Wei J, Zhang T, Li S.   +5 more
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

A Miniature Soft Sensor with Origami-Inspired Self-Folding Parallel Mechanism. [PDF]

Micromachines (Basel), 2022
Shi Y, Wang G, Sun W, Ya Y, Liu S, Fang J, Yuan F, Duo Y, Wen L.   +8 more
europepmc   +1 more source

Synthesis of Planar Parallel Mechanism [PDF]

, 2012
Parallel mechanisms are found as positioning platforms in several applications in robotics and production engineering. Today there are various types of these mechanisms based on the strcture, type of joints and degree of freedom.
Nigam, Kushagra
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Prediction of the RNA Tertiary Structure Based on a Random Sampling Strategy and Parallel Mechanism. [PDF]

Front Genet, 2021
Liu Z, Yang Y, Li D, Lv X, Chen X, Dai Q.   +5 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Novel Kinematically Redundant (3+1)-DOF Delta-Type Parallel Mechanisms

Robotics
Although parallel mechanisms are used in various fields, their application is often limited by singularities and a restricted workspace. Kinematic redundancy is a promising approach for mitigating these issues while also extending the functionality of ...
Pavel Laryushkin, Anton Antonov, Egor Ispolov, Maria Goncharova, Ayşe Ceren Aydil   +4 more
doaj   +1 more source

Workspace and Orientation Analysis of a Parallel Structure for Robotic Fingers

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2011
This paper investigates the workspace and the orientation capability of robotic fingers with a five-bar linkage and its variance defined by the parameter of a base link.
Wei YAO, Jian S DAI
doaj   +1 more source