Results 71 to 80 of about 7,215 (215)

Parallel repair mechanisms in plants and animals

Disease Models & Mechanisms, 2023
Timothy C. Byatt, Paul Martin
doaj   +1 more source

Structure Synthesis and Optimization of Feed Support Mechanisms for a Deployable Parabolic Antenna

Journal of Aerospace Technology and Management, 2016
In this paper, a systematic method to synthesize parallel mechanisms for feed support mechanisms based on screw theory is proposed. First, the motion requirement of the feed support mechanism is studied.
Xiaoke Song, Hongwei Guo, Rongqiang Liu, Zongquan Deng   +3 more
doaj  

Evaluation on Configuration Stiffness of Overconstrained 2R1T Parallel Mechanisms

Chinese Journal of Mechanical Engineering
Currently, two rotations and one translation (2R1T) three-degree-of-freedom (DOF) parallel mechanisms (PMs) are widely applied in five-DOF hybrid machining robots. However, there is a lack of an effective method to evaluate the configuration stiffness of
Xuejian Ma, Zhenghe Xu, Yundou Xu, Yu Wang, Jiantao Yao, Yongsheng Zhao   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Full Forward Kinematics of Lower-Mobility Planar Parallel Continuum Robots

Mathematics
In rigid lower-mobility parallel manipulators the motion of the end-effector is partially constrained due to a combination of passive kinematic pairs and rigid components.
Oscar Altuzarra, Mónica Urizar, Kerman Bilbao, Alfonso Hernández   +3 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Topology Synthesis of Assembly Parallel Mechanisms With Large Rotational Angle via FIS Theory

Journal of Robotics
To meet the large rotational angle requirements in component assembly, this study addresses the deficiency in topological configurations and synthesis theories for mechanisms with large rotational angle characteristics. The topology synthesis process for
Xinyu Jia, Yang Qi, Jiaxin Wang, Shijie Guo, Ruoyi Zhang, Mingyue Yan   +5 more
doaj   +1 more source

Type Synthesis of 2T2R Parallel Mechanisms Based on Optimal Transmission

Jixie chuandong, 2023
To synthesize a class of 2T2R parallel mechanisms with optimal transmission and large tilting ability, a type synthesis method for parallel mechanisms is proposed by combining the screw theory and the limb construction method.
Mao Jiang, Zhu Xiaofei, Chen Jin, Cai Wenlai   +3 more
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source