Results 61 to 70 of about 573,153 (341)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Cogent Engineering, 2020 This article considered the numerical simulation of multicomponent multiphase flow in porous media. The resulting system of nonlinear equations linearized by the Newton-Raphson method and solved with the iterative Generalized minimal residual method ...
Saltanbek T. Mukhambetzhanov +5 more
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Applied SciencesCurrently, research on the lattice Boltzmann method mainly focuses on its numerical simulation and applications, and there is an increasing demand for large-scale simulations in practical scenarios.
Shunan Tao +4 more
doaj +1 more source
An Improved Approach to the PageRank Problems
Journal of Applied Mathematics, 2013 We introduce a partition of the web pages particularly suited to the PageRank problems in which the web link graph has a nested block structure. Based on the partition of the web pages, dangling nodes, common nodes, and general nodes, the hyperlink ...
Yue Xie +3 more
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
An MPI parallel DEM-IMB-LBM framework for simulating fluid-solid interaction problems
Journal of Rock Mechanics and Geotechnical EngineeringThe high-resolution DEM-IMB-LBM model can accurately describe pore-scale fluid-solid interactions, but its potential for use in geotechnical engineering analysis has not been fully unleashed due to its prohibitive computational costs.
Ming Xia +5 more
doaj +1 more source
Nuclear Engineering and Technology, 2014 Scattering source calculations using conventional spherical harmonic expansion may require lots of computation time to treat full-coupled three-dimensional photon-electron transport in a highly anisotropic scattering medium where their scattering cross ...
JONG WOON KIM +2 more
doaj +1 more source