Results 41 to 50 of about 1,849,434 (247)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Analysis of Electromagnetic Wave Reflection through Isotropic Parallel Plates
Revista Elektrón, 2023 This study focuses on the reflection of electromagnetic waves through isotropic parallel plates using the interferometric method, instead of treating the system as a whole and solving it with boundary conditions.
German Eduardo Caro +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Dispersion in flow between parallel plates
, 1984 Laboratory experiments were conducted between two plexiglass, parallel plates, 121.9 cm long x 7.6 cm wide, to examine the relationship between dispersion and velocity as the aperture and roughness of the plates were varied. Experimental results from the
Dronfield, Douglas Gregory.
core +2 more sources
MathematicsIn this paper, we consider the unsteady flow of a compressible micropolar fluid between two moving, thermally isolated parallel plates. The fluid is characterized as viscous and thermally conductive, with polytropic thermodynamic properties. Although the
Nelida Črnjarić
doaj +1 more source
Study of the wettability of fusion relevant steels by the sodium potassium eutectic alloy NaK-78
Nuclear Materials and Energy, 2016 Several validation activities were dedicated to the High Flux Test Module (HFTM) of the International Fusion Materials Irradiation Facility (IFMIF) at the Karlsruhe Institute of Technology (KIT) in Germany.
Ali Abou-Sena +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both +7 more
wiley +1 more source
Slots in a parallel plate waveguide [PDF]
Radio Science, 1976 The problem of one or more infinite transverse slots in a parallel plate waveguide wall is considered. An integral equation is derived for the aperture electric field for the TMz case. The integral equation is solved by the method of moments. Steady state results are presented for the case where the exciting field is a TEM mode in the waveguide.
J. P. Quintenz, D. G. Dudley
openaire +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source