Results 51 to 60 of about 1,454,309 (287)

Telehealth-delivered naturalistic developmental behavioural intervention with and without caregiver acceptance and commitment therapy for autistic children and their caregivers: protocol for a multi-arm parallel group randomised clinical trial

BMJ Open, 2023
Introduction Timely access to early support that optimises autistic children’s development and their caregiver’s mental health is critical. Naturalistic developmental behavioural interventions (NDBIs) and acceptance and commitment therapy (ACT) are ...
Laurie McLay, Lisa Marie Emerson, Hannah Waddington, Jenna van Deurs, Jolene Hunter, Neville Blampied, Aaron Hapuku, Sonja Macfarlane, Nicholas Bowden, Lauren van Noorden, Mandy Rispoli   +10 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Resolving Jurisdictional Conflicts Between WTO and RTA Dispute Settlement: Toward an Interpretative Approach

Bond Law Review, 2018
In the last several decades there has been an exponential growth in the number of Regional Trade Agreements (‘RTA’s). In addition to creating a wide overlap of substantive rights and obligations with the World Trade Organization (‘WTO’), many RTAs are ...
Son Tan Nguyen
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

CoInDiVinE: Parallel Distributed Model Checker for Component-Based Systems

, 2011
CoInDiVinE is a tool for parallel distributed model checking of interactions among components in hierarchical component-based systems. The tool extends the DiVinE framework with a new input language (component-interaction automata) and a property ...
Beneš, Nikola, Křivánek, Milan, Černá, Ivana   +2 more
core   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

UNCITRAL Model Law on Cross-border insolvency: background, purpose and the scope of application

RUDN Journal of Law, 2008
The present article is dedicated to UNCITRAL Model Law on cross-border insolvency, the basic stages of its preparation and scope of application. The provisions of Model Law, concerning coordination of parallel proceedings within the case of cross-border ...
N V Kalinina
doaj  

Magnetic and electric properties in the distorted tetrahedral spin chain system Cu3Mo2O9

, 2011
We study the multiferroic properties in the distorted tetrahedral quasi-one dimensional spin system Cu$_3$Mo$_2$O$_9$, in which the effects of the low dimensionality and the magnetic frustration are expected to appear simultaneously.
H Eisaki, H Kuroe, H Ohta, Hamasaki T, K Oka, Kuroe H, Kuroe H, M Fujisawa, M Hase, S Hachiuma, S Okubo, T Hosaka, T Ito, T Sekine   +13 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source